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1610 Ch. 12 Terms
1610 Biology: Ch. 12 Terms
Question | Answer |
---|---|
pyramidines | Nitrogenous bases, each composed of a single ring of carbon and nitrogen atoms, e.g., thymine, cytosine, and uracil; components of nucleic acids. |
cytosine | A nitrogenous pyrimidine base that is a component of nucleic acids. |
Chargaff's rule | A relationship in DNA molecules based on nucleotide composition data; the number of adenines equals the number of thymines, and the number of guanines equals the number of cytosines. |
complementary DNA | DNA synthesized by reverse transcriptase, using RNA as a template. |
helicases | Enzymes that unwind the two strands of DNA double helix. |
RNA primer | The sequence of about five RNA nucleotides that are synthesized during DNA replication to provide a 3' end to which DNA polymerase adds nucleotides. |
leading strand | Strand of DNA that is synthesized continuously. |
telomeres | The protective end caps of chromosomes that consist of short, simple, noncoding DNA sequences that repeat many times. |
nucleotide | A molecule consisting of one or more phosphate groups, a five-carbon sugar (ribose or deoxyribose), and a nitrogenous base. |
adenine | A nitrogenous purine base that is a component of nucleic acid. |
phosphodiester linkage | Covalent linkage between two nucleotides in a strand of DNA or RNA; includes a phosphate group bonded to sugars of two adjacent nucleotides. |
X-ray diffraction | A technique for determining the spatial arrangment of the components of a crystal. |
DNA replication | The process by which DNA is duplicated; ordinarily a semiconservative process in which a double helix gives rise to two double helices, each with an "old" strand and a newly synthesized strand. |
lagging strand | A strand of DNA that is synthesized as a series of short segments, called Okazaki fragments, which are then covalently joined by DNA ligase. |
telomerase | A special DNA replication enzyme that can lengthen telomeric DNA by adding repetitive nucleotide sequences to the ends of eukaryotic chromosomes; typically present in cells that divide an unlimited number of times. |
deoxyribose | Pentose sugar lacking a hydroxyl (-OH) group on carbon -2'; a constituent of DNA. |
guanine | A nitrogenous purine base that is a component of nucleic acids and GTP. |
double helix | The structure of DNA, which consists of two antiparallel polynucleotide chains twisted around each other. |
topoisomerases | Enzymes that relieve twists and kinks in a DNA molecule by breaking and rejoining the strands. |
origin of replication | A specific site on the DNA where replication begins. |
Okazaki fragment | One of many short segments of DNA, each 100 to 1000 nucleotides long, that must be joined by DNA ligase to form the lagging strand in DNA replication. |
apoptosis | Programmed cell death; a normal part of an organism's development and maintenance. |
purines | Nitrogenous base with carbon and nitrogen atoms in two attached rings, e.g., adenine and guanine; components of nucleic acids, ATP, GTP, NAD+, and certain other biologically active substances. |
thymine | A nitrogenous pyrimidine base found in DNA. |
antiparallel | Said of a double-stranded nucleic acid in which the 5' to 3' direction of the sugar-phosphate backbone of one strand is reversed in the other strand. |
mutation | Any change in DNA; may include a change in the nucleotide base pairs of a gene, a rearrangement of genes within the chromosomes so that their interactions produce different effects, or a change in the chromosomes themselves. |
DNA polymerases | Family of enzymes that catalyze the synthesis of DNA from a DNA template by adding nucleotides to a growing 3' end. |
replication fork | Y-shaped structure produced during the semiconservative replication of DNA. |
DNA ligase | Enzyme that catalyzes the joining of the 5' and 4' ends of two DNA fragments; essential in DNA replication and used in recombinant DNA technology. |