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Proteases and RONS

QuestionAnswer
proteases play central role in host defense, removal of damaged tissue, tissue repair and inflammation
matrix metalloproteinases degrade extracellular matrix proteins
tissue inhibitors of metalloproteinases endogenous inhibitors of matrix metalloproteinases
serine proteases released from neutrophils
SERPINs endogenous inhibitors of serine proteases
synthetic MMP inhibitors peptidomimetics that bind to the catalytic zinc region and prevent activation of the enzyme
ROS reactive oxygen species such as superoxide and hydrogen peroxide
respiratory burst production of ROS by leukocytes as a host defense mechanism against invading bacteria or other microorganisms
lipoic acid anti-oxidant used in the treatment of multiple sclerosis
regulation of proteases by RONS activation of MMPs and inactivation of SERPINs
Created by: gss40
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