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Adhesion Molecules

TermDefinition
Selectins Play a role in tethering of leukocytes to vascular cells
L-selectin Constitutively expressed on leukocytes
P-selectin Constitutively expressed on platelets and endothelium
E-selectin Induced on endothelial cells
Integrins Play a role in firm adhesion and flattening
ICAM-1 Integrin ligand that is induced by cytokines
ICAM-2 Integrin ligand constitutively expressed on endothelium
VCAM-1 Binds to VLA-4
Transmigration Movement of leukocytes across endothelial cells
Natalizumab Monoclonal antibody against VLA-4
VLA-4 Integrin expressed on eosinophils, monocytes and T-cells
Etrlizumab Monoclonal antibody against alpha4, beta 7 integrin
Lifitegrast Monoclonal antibody against CD11a
Created by: gss40
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