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Adhesion Molecules
Term | Definition |
---|---|
Selectins | Play a role in tethering of leukocytes to vascular cells |
L-selectin | Constitutively expressed on leukocytes |
P-selectin | Constitutively expressed on platelets and endothelium |
E-selectin | Induced on endothelial cells |
Integrins | Play a role in firm adhesion and flattening |
ICAM-1 | Integrin ligand that is induced by cytokines |
ICAM-2 | Integrin ligand constitutively expressed on endothelium |
VCAM-1 | Binds to VLA-4 |
Transmigration | Movement of leukocytes across endothelial cells |
Natalizumab | Monoclonal antibody against VLA-4 |
VLA-4 | Integrin expressed on eosinophils, monocytes and T-cells |
Etrlizumab | Monoclonal antibody against alpha4, beta 7 integrin |
Lifitegrast | Monoclonal antibody against CD11a |