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Pharm Drugs

Ch. 20 Antineoplastic Drugs

TermDefinition
Allopurinol (Zyloprim) xanthine oxidase inhibitor used in the management of gout
Methotrexate (Amethopterin, MTX) a folic acid antimetabolite antineoplastic drug; attacks the cells at the S phase of the cell cycle; it interferes with purine and pyrimidine biosynthesis; also used to tx Rheumatoid arthritis
Tamoxifen an antineoplastic agent used to manage breast cancer
Bisphosphonates works to reduce osteoporosis by binding to osteoclasts
Prochlorperazine drug can be administered to manage the nausea and vomitting caused by antineoplastic agents
Cisplatin an example of a cell-cycle nonspecific antineoplastic agent
Antimetabolites antineoplastic agents most likely to cause liver problems
Doxorubicin an antineoplastic drug that is a potent cardiotoxin
Vincristine (Oncovin) or Vinblastine (Velban) associated with neurologic problems
Azathioprine, Cyclophosphamide, and Mercaptopurine have the action prolonged and toxicity increased by allopurinol, which is used to prevent hyperuricemia
Created by: Brookee185
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