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Burkitt's Lymphoma

QuestionAnswer
Clinical Features of Burkett's Lymphoma Extranodal presentation is common with 15-30% chance of marrow involvement. May present as a painless soft tissue lesion in the jaw and maxilla are endemically common in Africa. U.S. patients present with pelvis or abdominal masses.
Demographics of Burkett's Lymphoma Endemic form is most common in Africa predominantly in males and children 4-7 years old. Very prominent in malaria areas with a 95% EBV positivity rate. Sporadic form is common in 30 year olds.
Lesion Terminology of Burkett's Lymphoma Extranodal, painful, soft tissue swelling over the jaws with destruction of the underlying bone and patchy loss of lamina dura.
Microscopic Features of of Burkett's Lymphoma Microscopic features include medium sized cells with prominent nucleoli, scant cytoplasm, that are rapidly mitotically dividing. There are macrophages that impart a “starry sky appearance.”
Differential Diagnosis of Burkett's Lymphoma The differential diagnosis include erythema nodosum, leukemia, and sarcoidosis.
Treatment for of Burkett's Lymphoma Treatment generally consists of intensive chemotherapy including cyclophosphamide.
Created by: iTriston