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Enzyme Inhibitors

QuestionAnswer
What is a competitive inhibitor? Binds to the active site of an enzyme, preventing formation of ES complexes.
What are non-competitive inhibitors? Binds to the allosteric site and changes shape of the active site so it is no longer complimentary to the substrate, and ES complexes can no longer form.
What is end-product inhibition? After an enzyme-catalyzed reaction has reached completion, product molecules stay tightly bound to the enzyme so that no more product can be made.
How does Cyanide act as an inhibitor? CN- ions bind irreversibly to the enzyme found in mitochondria, inhibiting final stage of aerobic respiration.
How does Aspirin act as an inhibitor? Salycyclic acid binds to the enzyme that produces cell-signalling prostaglandins, reducing pain.
Created by: katieappleton