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Chronic Ulcerative Stomatitis

Chronic Ulcerative Stomatitis an immune-mediated disorder that affects the oral mucosa, probable cause is autoantibodies against a nuclear protein similar to p63 which involves epithelial growth and differentiation.
Clinical features of Chronic Ulcerative Stomatitis has a similar look to lichen plantus or desquamative gingivitis on the buccal mucosa with ulcers surrounded with white patchy zones of erythema and streaky keratosis.
Demographics and diagnosis of Chronic Ulcerative Stomatitis White women over 60 years old are most susceptible. Diagnosis needs a biopsy and tissue can be assessed by direct immunoflourescence that identifies the protein p63.
Microscopic features of Chronic Ulcerative Stomatitis Atrophic epithelium, large number of plasma cells and lymphocytes in inflammatory infiltrate.
Treatment and prognosis of Chronic Ulcerative Stomatitis Can treat with corticosteroids but it is not always effective. for patients with recalcitrant cases hydrochloroquine may be given which is an antimalarial agent.
Differential Diagnosis of Chronic Ulcerative Stomatitis Lichenoid mucositis, Lichen Plantus, Erythema Multiform, Lupus Erythematosus, Vesiculo-Bullous Disorder
Created by: a.juarez