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White Sponge Nevus
OMFP II
| Question | Answer |
|---|---|
| What is one type of epithelial genodermatosis of the oral cavity? | This is a White Sponge Nevus. |
| What are some alternative names for White Sponge Nevus? | Some alternative names are Cannon Disease and Familial White Folded Dysplasia. |
| What are some clinical features of White Sponge Nevus? | - It is a rare genetic condition as the autosomal dominant trait is caused by mutations in either the keratin 4 or keratin 13 genes. - These lesions may be evident at birth or early in childhood, but sometimes in the second decade. |
| What does White Sponge Nevus look like clinically? | - They are bilateral diffuse, wrinkled, white exophytic plaques. - They occur most commonly on the buccal mucosa. - They are asymptomatic and do not disappear when the cheek is stretched. Some patients report that the white areas may peel off. |
| What are some other areas where White Sponge Nevus can be found? | - They can be found on the ventral tongue, lips, soft palate, oral floor and alveolus. - Other areas include the nasal sinus, esophagus, larynx, and anogenital mucosa. |
| True or False: There is no gender predilection for White Sponge Nevus and this may be diagnosed as a congenital finding or in infancy, while others are diagnosed in early childhood. | True. |
| What is used to give a diagnosis of White Sponge Nevus? | The clinical and family history are important for a presumptive diagnosis. However, an exfoliative cytology is also helpful. Genetic analysis is warranted. |
| What are some microscopic features of White Sponge Nevus? | With a Papanicolaou stain, one finds the condensation of keratin filaments around the keratinocyte nuclei. A biopsy shows hyperparakeratosis and acanthosis of the epithelium. |
| What are some microscopic features of White Sponge Nevus? (continued) | The keratinocytes have perinuclear condensation of keratin monofilaments and intracellular edema. |
| What treatment is done in the case of White Sponge Nevus? | Treatment is not needed with clinical correlation. These lesions are not problematic and remain unchanged after the first few years of proliferation. |
| What can cause a White Sponge Nevus lesion to become more white and thickened? | Smoking or cheek biting habits can make this worse and these habits should be followed closely. |
| True or False: White Sponge Nevus has a good prognosis with no malignant transformation. | True. |
| What are differential diagnoses for White Sponge Nevus? | - Hereditary Benign Intraepithelial Dyskeratosis - Leukodema - Smokeless Tobacco Keratosis - Morsicatio - Candida - Proliferative Verrucous Leukoplakia - Verrucous Carcinoma |
Created by:
seema.prakash
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