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What are the clinical features of HSV1? - (in children) Diffuse gingivostomatitis (adults) Pharyngotonsillitis - Ulcers - Enlarged painful and erythematous gingiva, punched-out areas on free margins - Perioral lesions and self-inoculation are common - (secondary) Ruptured blisters on lips
What are the demographics for HSV1? - 70-90% of children - In less developed countries, the exposure is at a higher rate - Prevalence of infection increases with age - Peak incidence: 2-3 years of age - Recurrent HSV1 occurs in 15-50% of population in USA
Lesion description of HSV1 Single or multiple small 3-10 mm ulcerations with red lining and a yellow center, slightly raised, found along the hard palate, gingiva, or lips
What are the microscopic features of HSV1? - Epithelium in superficial layer has a vesicle with acantholysis where the desmosomes are broken down 3 M's: - Multinucleated cells - Margination: Nuclear matter pushed to the nucleus periphery - Molding: Infected cells molding to each other
What is the treatment for HSV1? Palliative - Maalox-containing “magic mouthwash” - Increase fluids (Recurrent HSV): Denavir cream Famvir Valtrex Zovirax Abreva topical cream
What are the differential diagnoses of HSV1? - Aphthous stomatitis - Herpes zoster - Herpangina - Erythema multiforme
Created by: celinapyune
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