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Blastomycosis

TermDefinition
Clinical Features of Blastomycosis May range from asymptomatic to mild symptoms Acute and chronic (more common) resembles pneumonia with high fever, chest pain, malaise, night sweats, and productive cough with mucopurulent sputum.
Demographics of Blastomycosis There is a male predilection with a ratio of 9:1. Usually associated in areas with H. capsulatum affecting the eastern half of the U.S. and parts of Canada. Sporadic in Africa, India, Europe, and South America. Rarely found in immunosuppressed patients.
Cutaneous Lesions of Blastomycosis Cutaneous lesions usually represent the spread of infection from the lungs, although occasionally they are the only sign of disease. Such lesions begin as erythematous nodules that enlarge, becoming verrucous or ulcerated .
Microscopic Appearance of Blastomycosis A mixture of acute inflammation and granulomatous inflammation surrounding variable numbers of yeasts; 8 to 20 ┬Ám in diameter. Characterized by a doubly refractile cell wall and broad attachment between the budding daughter cell and the parent cell.
Differential Diagnosis of Blastomycosis The differential diagnosis are malignant tumors, tuberculosis, and tertiary syphillis.
Treatment for Diagnosis of Blastomycosis Itraconazole should be prescribed for mild to moderate disease. If severe, amphotericin B is indicated. Immunosuppressed patients need amphotericin B and 6-12 months of intraconazole.
Radiographic Features of Blastomycosis Chest radiographs may appear normal, or they may demonstrate diffuse infiltrates or one or more pulmonary or hilar masses without presence of calcification.
Oral Lesions of Blastomycosis Have an irregular, erythematous or white intact surface, or they may appear as ulcerations with irregular rolled borders and varying degrees of pain.
Created by: iTriston