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Lymphatic System 3
Bio 169
Questions | Matches |
---|---|
Adaptive (Specific) Defenses | *Specific resistance(immunity) *Responds to specific antigens *With coordinated action of T Cells(Thymus) and B Cells(Bone Marrow with NK Cells) |
Two Types Of Adaptive Defense | *Cell Mediated immunity (T cells deciding who to kill) *Antibody Mediated immunity (B Cell) |
Cell Mediated Immunity | *T Cells *Defends against abnormal cells and pathogens inside cells *Use perforin and granzymes |
Antibody Mediated (Humoral-Bone Marrow) Immunity | *B Cells *Defends against pathogens(antigens) in the body fluids *Use antibodies |
Forms of Immunity | *Innate(Born with) *Adaptive(acquire these these through life) |
Innate Immunity | *Present at birth |
Adaptive Immunity | *After Birth 1. Active Adaptive- antibodies develop after exposure to antigen a. Naturally acquired active immunity b.Artificially induced active immunity 2.Passive Adaptive- antibodies are transferred from another source a. Naturally acquired passiv |
1. Active Immunity Types | -Naturally acquired active immunity From environmental exposure to pathogens(ex. kids playing in dirt -Artificially induced active immunity Through vaccines containing attenuated(weak) patogens |
2. Passive Immunity Types | - Naturally acquired passive immunity Antibodies acquired from their mother -Artificially induced passive immunity By an injection of antibodies(ex. injection against rabies) |
Four Properties of Adaptive(acquired) Immunity | 1. Specificity 2. Versatility 3.Memory 4. Tolerance |
Specificity | -Each T and B Cell respond only to a specific antigen and ignores all others |
Versatility | -Any antigen any time -Active lymphocytes makes clones(create more lymphocytes) of itself that are sensitive to the same antigen |
Memory | -Two groups of cells are made when antigen encountered: active(now) and inactive(later) -Inactive group does not wake up until you are exposed a second time and then they remember antigen and strikes with faster, longer, more effective attack |
Tolerance | -Immune system ignores normal antigens (self-antigens) |
T Cells | -Provide cell mediated immunity -Defends against abnormal cells and pathogens inside cells |
B Cells | -Provide Anti-Body mediated immunity -Defend against antigens and pathogens in body fluids |
Major Types of T Cells | 1.Cytotoxic T Cells(Tc) 2.Memory T Cells 3.Helper T Cells(Th) 4.Suppressor T Cells(Ts) |
1. Cytotoxic T Cells(Tc) | -Responsible for cell mediated immunity |
2. Memory T Cells | -Produced and activated if pathogen occurs again later |
3. Helper T Cells(Th) | -Stimulates responses of T cells and B cells, especially active B cells |
4. Suppressor T Cells(Ts) | -Inhibit stop function of T cells and B cells when attack should end |
Antigen Recognition by T Cells | 1. CD Markers- -also called cluster of differentiation markers 2. CD3 Receptor(receive) Complex -Found in all T cells -Present at all times |
Two Types of CD Markers | 1. CD8 Markers- -found on cytotoxic T cells and suppressor T cells (Goes and Kills) -Respond to antigens on Class l MHC proteins 2. CD4 Markers- -Found on Helper T Cells (Tell B cells to make antibodies) -Respond to antigens on Class ll MHC protie |
CD8 and CD4 | -Both bind to CD3 receptor complex -Prepare cell for activation |
Antigen Presentation | T Cells cant recognize antigen unless it is bound to a glycoprotein in the plasma membrane of another cell and presented |
Membrane Histocompatibility Complex(MHC) proteins | -Also called Human leukocyte antigens (HLAs) -Has a narrow groove that binds an antigen for presentation to a T cell -Class l for cytotoxic T cells + Class ll for Helper T cells |
Two Classes of MHC proteins | 1. Class l -Found in membranes of all nucleated body cells -Mature cytotoxic T cells respond to MHC l 2. Class ll -Found in membranes of antigen-presenting cells(APs) -Mature Helper T cells respond to MHC ll |