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macromolecules
BIOL 288
Question | Answer |
---|---|
what are the 4 biological molecules | proteins, nucleic acids, lipids and carbs |
what are lipids | nonpolar, uncharged hydrocarbons, classified by solubility. soluble in org solvents, insoluble in water |
what are the functions of lipids | energy storage, compartmentalization, cell signalling, immune and inflammatory responses |
what is lipid energy storage | via trigylcerides and fatty acids |
what are triglycerides | fat storage, glycerol and 3 fatty acids. 3 OH ester bonds with FA |
what are fatty acids | amphipathic, long unbranched hydrocarbon tails(hydrophobic), carboxyl group head, hydrophilic, charged at neutral pH |
what is compartmentalization of lipids | phospholipids and amphipatheic.. used in membranes to separate cell and organelles from external aqueous environment |
what are phospholipids | amphipathic, hydrophilic polar head and hydrophobic fatty acid tail |
what does phospholipid consist of | glycerol backbone, 2 FA, 1 phosphate linked to 3rd OH of glycerol, small hydrophilic head group bound to phosphate |
Do lipids attract eachother | no, water excludes them attracting itself, b/c cant form H bonds |
what is cell signaling-lipds | steroids and membrane lipids signalling |
what are steroids | key signalling molecules(animals cholesterol, plants sterols) differ in the aliphatic side chains |
what are other signalling lipids | membrane lipids cleaved to form secondary messengers. eg.G proteins |
what are the immune nad inflammatory response of lipids | leukotrienes, prostaglandins, prostacyclins, thromboxanes are lipid signalling associated with inflammatory responses, derived from cell memb |
what are carbs | simple sugars(mono-) and polymers(poly-) |
what are monoscharrides | (CH2O)n . has carbon atom backbone linked to single OH (except COO group) |
what group defines the two types of sugars | carbonyl |
what are the two types of sugars | aldose and ketose |
what is aldose | carbonyl group at one end of sugar forms aldehyde group 6C |
what is ketose | carbonyl group found at internal chain position 5C |
what are isomers | the chemical formula doesnt define type of sugar. |
what are glucose and fructose | isomers. same chemical formula, but atoms arranged differently. one is aldose and other ketose. |
what are disacchrides | monosac linked by glycosidic bond via condensation/dehydration rxn. |
what are examples of disachhrides | sucrose(glu and fru-alpha 1,2) lactose (gala and glu-beta 1,4) maltose(2 glu -alpha 1,4) |
what are polyscharrides | long chains of mono linked by glycosidic bonds. |
what is there variability in polyscarrides | type of mono(one or many types), branching, type glycosidic bonds |
what is Extracellular Glycosaminoglycans | many different mono producing very different molecules. |
what are only glucose mono, but have very different molecules | glycogen, starch, cellulose |
what is cellulose | animals digest via symbiosis with bacteria. tight packed with beta 1,4 |
what are modified mono | the OH group changed with functional groups. eg. chitin, consists of monomers of N-actetylglucosamine |
hwo do sugars modify molecules | carbs can be covlantly linked to proteins (glycoproteins) and membrane lipids(glycolipids) and act like "labels" for other protiens to "read" |
what are the functions of carbs | energy(glucose, glycogen, starch),, structure (cellulose, GAG), cell signalling, cell recognition, protein and enzyme function, cell surface protection(glycocalyx) |
what do nucleotides consist of | 5C sugar, base, phosphate |
how are bases linked to sugars | covalently via C1 prime (n-glycosidic bond) |
how are sugars linked to phosphate | C5 prime of sugar (phosphoester bond) |
what are nucleoside | base and sugar |
what are nucleotide | base, sugar and phosphate |
what are the functions of nucleotides | info storage in forms RNA/DNA, energy(ATP,NADH,GTP), coenzymes, signaling, enzymes |
what are nucleotide triphosphates | serve as building blocks of nucleic acids with are long polymers of deoxyribonucleotides or ribonucleotides |
how are nucleic acids linked together | covalently by phosphodiester bonds btwn C3 hydroxyl group of one nucleotide and the phosphate group of another nucleotide |
how do nucleic acids have directionality | 5' and 3' end of how they are linked |
the DNA double helix | bases held in center H bonds, weak. backbone is sugar and phosphate |
what is the structure of amino acids | alpha carbon, carboxyl group, amino group, R group. ionized at physiological pH |
what is the function of amino aicds | building blocks of proteins, (linked via peptide bonds), energy (TCA cycle) |
how are polymers constructed | covalently linking small organic molecules into long chains |
cells contain what 3 types of macromolecules | polysacchrides, proteins and nucleic acids |
what are the common mechanisms of macromolecules | synthesized stepwise via monomers grows by one end via dehydration rxn, catalyzed by specific carrier molecules/enzymes, monomers added in sequence, have inherent directionality |
what does stepwise addition create | a large diversity of complex molecules |
what does individual covalent bonds create | rotation of atoms, flexibility and ability of many configurations |
how is the unltimate shape of macromolecule constrained | weaker noncovalent bonds that are additive and influence interaction of large marcomolecule complexes |