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Nucleic Acid set 5

Nucleic Acid Module set 5

stable, heritable change in nucleotide sequence and may or may not have an effect on the phenotype of an organism mutation
mutations can be classified in terms of their effect on phenotype
change colonial or cellular morphology morphological mutations
kill the organism lethal mutations
expressed only under certain conditions (e.g., high temperature) conditional mutations
changes in metabolic capabilities biochemical mutations
have mutations in biosynthetic pathways,cannot synthesize product of pathway,require product of pathway as nutrient in minimal growth media auxotrophs
grow in minimal media without supplements prototrophs
resistance to pathogen, chemical, or antibiotic resistance mutations
most prevalent form of gene wild type
wild type -> mutant form forward mutations
mutant phenotype -> wild type phenotype reverse mutations
Permanent change in the primary sequence of nucleic acids genetic mutations
What are the two types of genetic mutation? spontaneous and induced
Due to natural phenomena spontaneous mutation
cosmic radiation,DNA pol mistakes,Happens ~ 1 in every 106-1010 divisions,1 mutation in every billion bacteria spontaneous mutation
Produced by chemical or physical agents called mutagens induced mutation
Physical mutagen UV light
Base analogues, Alkylators, Nitrous acid chemical mutagen
What are the two types of mutation? Substitution and Frameshift
Created by: kprout