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Module 10 Set 8
Question | Answer |
---|---|
regulation of metabolism is important for | conservation of energy and materials |
regulation of metabolism in the maintenance of | metabolic balance despite changes in environment |
Three major mechanisms: | metabolic channeling, regulation of the synthesis of a particular enzyme (transcriptional and translational), and direct stimulation or inhibition of the activity of a critical enzyme |
metabolic channeling: | Differential localization of enzymes and metabolites |
Compartmentation: | differential distribution of enzymes and metabolites among separate cell structures or organelles |
compartmentation can generate | marked variations in metabolite concentrations |
Two important reversible control measures | allosteric regulation and covalent modification |
effector binding alters | shape of active site |
enzyme inactive | can’t bind substrate |
covalent modification of enzymes | reversible addition or removal of a chemical group alters enzyme activity |