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Module 10 Set 8

regulation of metabolism is important for conservation of energy and materials
regulation of metabolism in the maintenance of metabolic balance despite changes in environment
Three major mechanisms: metabolic channeling, regulation of the synthesis of a particular enzyme (transcriptional and translational), and direct stimulation or inhibition of the activity of a critical enzyme
metabolic channeling: Differential localization of enzymes and metabolites
Compartmentation: differential distribution of enzymes and metabolites among separate cell structures or organelles
compartmentation can generate marked variations in metabolite concentrations
Two important reversible control measures allosteric regulation and covalent modification
effector binding alters shape of active site
enzyme inactive can’t bind substrate
covalent modification of enzymes reversible addition or removal of a chemical group alters enzyme activity
Created by: Whereis_raye