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Oncology - Hoa
Oncology Notes
| Question | Answer |
|---|---|
| SE of Alkylating Agents | Most toxic chemo. Myelo, Secondary malignancy, N/V (high) |
| Cyclophosphamide (Cytotan) | Alkylating Agents - Hemorrhagic cystitis (Mesna) |
| Dacarbazine | Alkylating Agents |
| Chlorambucil (Leukeran) | Alkylating Agents |
| Ifosfamide (Ifex) | Alkylating Agents - Hemorrhagic cystitis (Mesna) |
| Procarbazine (Matulane) | Alkylating Agents |
| Carmustine | Alkylating Agents |
| Melphalan (Alkeran) | Alkylating Agents |
| Temozolamide (Temodar) | Alkylating Agents |
| SE of Anthracylines | Cardiotoxicity, Orange/Red color, Extravasation injuries |
| Bleomycin (G2 Phase) | Anthracyclines (Pneumotitis SE). Max dose 400 units |
| Dactomomycin (Cosmegen) | Anthracyclines |
| Daunorubicin (Daunoxome) | Anthracyclines (Cardiotoxicity). Max dose 550mg/m2 |
| Doxorubicin (Adriamycin) | Anthracyclines (Cardiotoxicity). Max dose 550mg/m2 |
| Epirubicin | Anthracyclines (Cardiotoxicity). Max dose 900mg/m2 |
| Idarubicin | Anthracyclines (Cardiotoxicity). |
| Mitomycin | Anthracyclines |
| Mitoxantrone | Anthracyclines |
| Topotecan | Topoisomerase (I) |
| Irinotecan | Topoisomerase (I) - SE Diarrhea (give Loperamide) |
| Etoposide | Topoisomerase (II) |
| Teniposide | Topoisomerase (II) |
| SE of Heavy Metals | Neurotoxicity, Nephrotoxicity, N/V (high) |
| Cisplatin | Heavy metal (SE= Ototoxicity) |
| Carboplatin | Heavy metal |
| Oxaliplatin | Heavy metal |
| MTX | Antimetabolites- S phase Specific (Folate Antagonist) |
| Pemetrexed (IV only) | Antimetabolites- S phase Specific (Folate Antagonist) = rash (use steroid) |
| Capacitabine (Xeloda) - Pro-drug 5-FU | Antimetabolites- S phase Specific (Pyrimidine analogs) |
| Floxuridine | Antimetabolites- S phase Specific (Pyrimidine analogs) |
| Fluouracil, 5-FU (Adrucil) | Antimetabolites- S phase Specific (Pyrimidine analogs) = Diarrhea |
| Gemcitabine (Gemzar) | Antimetabolites- S phase Specific (Pyrimidine analogs) |
| Mercaptopurine (Purinethol) | Antimetabolites (Purine analog).Metabolized by XO --> Allopurinol |
| Vincristine (Oncovin) | Mitotic Inhibitors -M phase: (Alkaloids) |
| vinblastine (Velban) | Mitotic Inhibitors -M phase: (Alkaloids) |
| vinorelbine (Navelbine) | Mitotic Inhibitors -M phase: (Alkaloids) |
| Docetaxel (Taxotere) | Mitotic Inhibitors (Taxenes) - Fluid retention |
| Paclitaxel (Taxol) | Mitotic Inhibitors (Taxenes) = Neuropathies, infusion reaction (must use with Dexame, Benadryl and Famotidine/Ranitidine) |
| Imatinib (Gleevac) | Protein Tyrosine Kinase Inhibitors (only use pt with positive Philadelphia Chromosone positive) |
| Erlotinib (Tarceva) | Protein Tyrosine Kinase Inhibitors (Major SE = rash, diarrhea) |
| Bevacizumab (Avastin) | Protein Tyrosine Kinase Inhibitors (BBW GI, Intra-abdominal, Wound dehiscene) |
| Trastuzumab (Herceptin) | Biologic Therapies (for Breast cancer) |
| Rituximab (Rituxin) | Biologic Therapies (for Non-Hodgkin's lymphoma) - (SE= infusion reaction. Pretreat APAP and Benadryl) |
| Tamoxifen | Antiestrogens (Pre and Postmenopausal) |
| Bicalutamide (Casodex) | Antiandrogen |
| Ansatrolzole (Arimidex) | Aromatase inhibitors (postmenopausal only) |
| Exemestane (Aromasin) | Aromatase inhibitors (postmenopausal only) |
| Letrozole (Femara) | Aromatase inhibitors (postmenopausal only) |
| Leuprolide (Lupron) - SC | LHRH agonist |
| Goserelin (Zoladex) - SC | LHRH agonist |
| Dexrazoxane (Zinecard) | Antidote of Cardiotoxicity (-rubucin) |
| Dexrazoxane (Totect) | Antidote for Extravasation cause by Anthracycline |
| Amifostine (Ethyol) | Antidote for Nephrotoxicity caused by Cisplatin |
Created by:
_Tom_
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