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Antibiotics + Others
Mics
| Question | Answer |
|---|---|
| Aminoglycosides | Concentration dependent kill. Gm(-), including pseudmonas, complicated UTI, Endocarditis. No Anerobes and Atypical |
| Genta/Tobramycin Pk and Tr | (5-10)/ <1.5. |
| Amikacin Pk and Tr | (15-30) and <5 |
| Penicillin | Time Dependint Kill |
| Zosyn | Piperacillin/Tazobactam (anti-pseudomonal) |
| Augmentin | Amoxicillin/Clauvulanic acid |
| Unazyn | Ampicillin/Sulbactam |
| Primaxin | Imipenem/Cilastatin (Time dependent kill) |
| Merrem | Meropenem (Time dependent kill) |
| Invanz | Ertapenem (not agasint Pseudomonas/Acinetobacter) |
| Cephalosphorins | Time Dependent Kill |
| Fluoroquinolones | Centrentration dependent kill |
| FQ that CI in diabetes | Gatifloxacin (Tequin) |
| FQ does not need Renal adjustment (Live) | Moxifloxacin (Avelox) |
| Macrolides (ACE -mycin) | Bacteriostatic (can be used if PCN allergy) |
| Anerobes (MC) | Bacteriostatic and Bactericidal (SE = diarrhea) |
| Tetracyclines | Bacteristatic (mainly atypicial = mycoplasma, Chlamydia) and Dendal Doxycycline) - CI = <8 and Preg |
| Chloramphenicol (Chloromycetin) | Bacteriostatic |
| Vancomycin | Time dependent kill |
| Linezolid (Zyvox) | bacteriostatic. Also treat VRE |
| Synercid | Quinupristin/Dalfopristin (Bacterialcidal) |
| Daptomycin (Cubicin | Concentration dependent kill (not compatible with dextrose). Not for pneumonias |
| Complaint TB treatment | Isoniazid + Rifampin + Pyrazinamide + Ethambutal (daily 2 mo) then 2 drugs = 6 mo |
| Non Complaint TB treatment | 4 drugs = 2-3 times then 2 drugs = 2-3 times |