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Cancer genes

Oncogenes and tumor suppressor genes

GeneTypeChromosomeAssociated tumor
bcl-2 Oncogene Follicular and undifferentiated lymphomas (inhibits apoptosis)
erb-B2 Oncogene Breast, ovarian and gastric carcinoma
ras Oncogene Colon carcinoma
L-myc Oncogene Lung cancer
N-myc Oncogene Neuroblastoma
ret Oncogene Multiple endocrine neoplasia (MEN) type II and III
c-kit Oncogene Gastrointestinal stromal tumor (GIST)
Rb tumor suppressor gene 13q Retinoblastoma, osteosarcoma
BRCA1 tumor suppressor gene 17q Breast and ovarian cancer
BRCA2 tumor suppressor gene 13q Breast cancer
p53 tumor suppressor gene 17p Most human cancers, Li-Fraumeni syndrome
p16 tumor suppressor gene 9p Melanoma (melanoma is on Nine)
APC tumor suppressor gene 5q Colorectal cancer (associated with FAP)
WT1 tumor suppressor gene 11p Wilm's tumor
NF1 tumor suppressor gene 17q Neurofibromatosis type 1
NF2 tumor suppressor gene 22q Neurofibromatosis type 2
DPC tumor suppressor gene 18q Pancreatic cancer (deleted pancreatic cancer)
DCC tumor suppressor gene 18q Colon cancer. DCC (deleted in colon cancer)
abl Oncogene CML
c-myc Oncogene Burkitt's lymphoma
Created by: ddecampo