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YR ch 20, 21
Anatomy and Physiology 2 BIO 106 UCC
Question | Answer |
---|---|
What are pathogens? | Organisms that cause disease such as bacteria, viruses, fungi, and prions. |
What are mutations? | Changes in DNA sequence. |
What is the immune system made up of? | Cells, proteins, lymphatic system and circulatory system. |
What are barriers? | Skin, mucus membranes, digestive acids, vaginal acids, competing bacteria that work with the body. There is also vomiting, urination, and defecation. Even tears and saliva because they contain lysosyme (kills bacteria) |
What is nonspecific defense? | Uses phagocytes, natural killer cells, complement system and inflammation to address "general" issues or infections. Ex: rise in temperature from a fever or use of Interferons. |
What are interferons? | Act like a silent alarm, warning other cells of an infection. |
What is specific defense? | Helps the body defend against "specific" pathogen aka antigen and mounts an immune response using lymphocytes ( B and T cells) that react using MHC or producing antibodies. |
What is a virus? | Non-living because they can't reproduce or carry out metabolic processes on their own. Can cause disease and have genetic material when they infect other organisms. |
What is a bacteria? | Can reproduce. Some bacteria are helpful because they recycle sewage and decompose dead animals. |
The type of genetic material a virus has can determine? | Its nature and how it's classified. |
What are parts of a virus? | Genetic material (RNA or DNA) -capside: protein coat -viral envelope: not all viruses have them but those that do may consist of glycoproteins, phospholipids, and proteins that help with infection and infiltration. Ex: AIDS |
Viruses are specific about the host cell they infect by? | Using "lock and key" method |
What are examples of viruses? | smallpox, common cold, polio, chickenpox, AIDS |
Viruses inject their genetic material or use what else? | Endocytosis to get thru the plasma membrane of the host cell. |
What are vaccines? | Weakened versions of a virus that when injected help mount an immune response from the body.EX: smallpox |
What are antiviral drugs? | They interfere with nucleic acid synthesis of a virus. Ex: AZT is a drug used on HIV. |
What are prions? | Simpler than virus. Infectious proteins that cause brain degeneration. EX: mad cow disease. |
Transmissibility- a factor of how dangerous a pathogen is | How easily it passes from person to person |
Mode of transmission-a factor of how dangerous a pathogen is | How it is transmitted. |
Virulence- a factor of how dangerous a pathogen is | Damaging effects of a pathogen. |
What is lymph? | A fluid made of WBC, proteins, fat and some pathogens |
What is the lymph flow? | Lymph enters lymphatic system and merges into different pathways, from capillaries to ducts, until it flows back into the heart. |
1. lymphatic capillaries | Where lymph is collected from blood capillaries. |
2. lymphatic vessels | Lymph is brought here and passed through lymph nodes. |
3. lymphatic trunks | Lymph is brought through trunks. |
4. lymphatic ducts | Lymph is deposited back into circulation to the heart from here using the veins of the neck. |
What is the thoracic duct (aka left thoracic duct)? | It collects lymph from the left side of the body and areas below the thorax beginning at the cisterna chili. |
What is the right lymphatic duct (aka right thoracic duct)? | Drains lymph from the upper right side of the body (right side of thorax, neck, head, and right arm) |
What are lymph nodes? | Bean-shaped bodies that occur alongside lymphatic vessel and abundant where those vessels merge to form a lymphatic trunk (groin, armpit, and mammary glands) |
What is the function of thymus? | It is where T cells mature. |
What is the largest lymphatic organ? | Spleen (filters the blood, destroys old red blood cells and recycle their parts, provides a reservoir of blood,active in immune response, produces blood cells during fetal development) |
What is nonspecific barrier? | The skin and mucous membrane. |
What are nonspecific defense in regards to the immune response? | Monocytes become macrophages and use phagocytosis to engulf general pathogens without discrimination. |
What are specific defense in regards to the immune response? | Involves immune response which uses lymphocytes to defend against a specific antigen or foreign element. |
What is the most important aspects of the immune response? | Memory, specificity and ability to differentiate self from non-self. |
What are T cells? | Responsible for cell-mediated immunity. Uses MHC to deal with cells carrying the wrong genetic ID. Originates in bone marrow and matures in thymus. Attacks self-cells that have been compromised and non-self cells. |
What are B cells? | Responsible for anti-body mediated immunity. Responds to antigens or pathogens. Originates in bone marrow and matures there. Attacks antigens. Causes the production of antibodies through plasma cells and memory cells. |
What is active immunization? | Body mounts immune response. Use of vaccines ( people are injected with a weakened form of a pathogen). Has a long term immunity. |
What is passive immunization? | Body doesn't mount immune response. Involves injection of antibodies rather than natural response. Ex: breast milk. Immunity is temporary. |
How does HIV work? | By invading helper T-cells which are part of our immune system. |
Step 1 of how HIV infects: Invade | HIV has a viral envelope. It will use its glycoproteins to bind to the receptor proteins of the host cell and fuse with the plasma membrane to get inside. |
Step 2 of how HIV infects: reverse transcriptase | Provirus will do the usual steps of DNA to mRNA. Proteins will use proviral genes to make new viral proteins or a new generation of virus offspring that will be released to invade other host cells. |
Step 3 of how HIV infects: remain | A provirus never leaves the host cell's genome. |