Busy. Please wait.
Log in with Clever

show password
Forgot Password?

Don't have an account?  Sign up 
Sign up using Clever

Username is available taken
show password

Make sure to remember your password. If you forget it there is no way for StudyStack to send you a reset link. You would need to create a new account.
Your email address is only used to allow you to reset your password. See our Privacy Policy and Terms of Service.

Already a StudyStack user? Log In

Reset Password
Enter the associated with your account, and we'll email you a link to reset your password.
Didn't know it?
click below
Knew it?
click below
Don't Know
Remaining cards (0)
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.

  Normal Size     Small Size show me how


Local Anesthesia CH. 3 Pharmacology of Vasocontrictors PG. 41-53

What happens after a local anesthetic is injected into the tissues? Blood vessels in the area dilate, resulting in increased perfusion at the site.
When blood vessels dilate, resulting in increased perfusion at the site of injection what reactions occur? Increased rate of absorption into cardiovascular system removing it from the injection site. Higher plasma levels. Increase risk of toxicity. Decrease in depth and duration due to anesthetic diffusing away from injection site. Increased bleeding at site.
Why are vasoconstrictors important additions to local anesthetic solution? decrease blood flow at the site of administration, absorption of the anesthetic in the cardiovascular system is slowed resulting in lower blood levels. Increases the duration of action.
What are local anesthetics chemically identical or similar to? Sympathetic nervous system mediators epinephrine and norepinephrine
What are naturally occurring catecholamines of the sympathetic nervous system? Epinephrine, norepinephrine, and dopamine
Direct-acting drug exert their action directly on adrenergic receptors
Indirect-acting drugs releasing norepinephrine from adrenergic nerve terminals
Mixed-acting drugs both direct and indirect acting drugs
What happens when the alpha receptors are activated? produces a response that includes contraction of smooth muscle in blood vessels (vasoconstriction)
What are alpha 1 receptors? excitatory-postsynaptic
What are alpha 2 receptors? inhibitory-postsynaptic
What happens when the beta receptors are activated? smooth muscle relaxation (vasodilation and bronchodilation) and cardiac stimulation (increased heart rate and strength of contraction)
What can amphetamines do? act indirectly by causing the release of the catecholamine norepinephrine from storage sites in adrenergic nerve terminals and may exert direct action on alpha and beta receptors
Tachyphylaxis Successively repeated doses of drugs will prove to be less effective than those given previously because the depletion of norepinephrine from storage sites.
What is the epinephrine reaction? Sufficient epinephrine can be absorbed to cause sympathomimetic reactions such as apprehension, tachycardia, sweating, pounding in the chest (palpitation).
What vasoconstrictor should never be used in dentistry? combination of epinephrine and norepinephrine
What is the most common effective vasoconstrictor used in dentistry today? Epinephrine
What is another name for epinephrine? Adrenalin
Why is sodium bisulfite added to epinephrine solutions? Delay its deterioration
Epinephrine is used as a vasoconstrictor predominately for what? Hemostasis
What is used as management of acute asthmatic episodes (bronchiole)? Epinephrine
Epinephrine's action is terminated by what? Reuptake by adrenergic nerves
Clinical manifestations of epinephrine overdose include what? fear and anxiety, tension, restlessness, throbbing, headache, tremor, weakness, dizziness, pallor, respiratory difficulty, and palpitation.
When should you limit or avoid the use of epinephrine/ vasoconstrictor? Cardiovascular compromised patients, ASA III and ASA IV
This vasoconstrictor should not be used at all in local anesthetic, according to some authorities what is it? Norepinephrine
T/F Norepinephrine is used as management for hypotension. True
What are the systemic actions of levonordefrin? less cardiac and CNS stimulation than epinephrine
What is stated according to Epinephrine and Levonordefrin? Levonordefrin has the same effects as epinephrine but to a lesser degree.
What factors should be considered if and when using a vasoconstrictor? Length of the dental appointment, need for hemostasis during and after, postoperative pain control, medical status of the patient.
What happens when tissue level of epinephrine declines? rebound vasodilatory effect
Vasopressors in local anesthetics solution must be weighed against the benefits and risks of using a plain local anesthetic. What are the groups in this category? Patients with significant cardiovascular disease ASA III and IV, certain noncardiovascular disease ( thyroid dysfunction, diabetes, sulfite sensitivity), MAO inhibitors, tricyclic antidepressants, and phenothiazines
Epinephrine is contraindicated in patients that have clinical evidence of what? Hyperthyroid state
What is absolutely contraindicated in patients receiving tricyclic antidepressants? administration of levonordefrin or norepinephrine
Created by: daisenmurray
Popular Dentistry sets




Use these flashcards to help memorize information. Look at the large card and try to recall what is on the other side. Then click the card to flip it. If you knew the answer, click the green Know box. Otherwise, click the red Don't know box.

When you've placed seven or more cards in the Don't know box, click "retry" to try those cards again.

If you've accidentally put the card in the wrong box, just click on the card to take it out of the box.

You can also use your keyboard to move the cards as follows:

If you are logged in to your account, this website will remember which cards you know and don't know so that they are in the same box the next time you log in.

When you need a break, try one of the other activities listed below the flashcards like Matching, Snowman, or Hungry Bug. Although it may feel like you're playing a game, your brain is still making more connections with the information to help you out.

To see how well you know the information, try the Quiz or Test activity.

Pass complete!
"Know" box contains:
Time elapsed:
restart all cards