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USMLE

MSK Derm 1

QuestionAnswer
What makes up the unhappy triad in a knee injury? Damage to ACL, MCL & medial meniscus Caused by clipping from the lateral side
What are the rotator cuff muscles? SITS Supraspinatus, Infraspinatus, Teres minor, Subscapularis
Failure of longitudinal bone growth leads to short limbs Achondroplasia
Heberden's & Bouchard's nodes Heberdon's-DIP; Bouchard's-PIP a/w osteoarthritis
Failure of normal bone resorption leads to thickened, dense bones Osteopetrosis
"Brown tumors" a/w Osteitis fibrosa cystica- caused by hyperparathyroidism
Abnormal bone architecture caused by increase in both osteoblastic & osteoclastic activity Paget's disease of the bone
Bone is replaced by fibroblasts, collagen & irregular bony trabeculae Polyostotic fibrous dysplasia
Joint problem a/w temporal arteritis Polymyalgia rheumatica
Progressive symmetric proximal muscle weakness caused by CD8+ T-cell-induced injury to myofibers Polymyositis
Polymyositis w/ "shawl & face" skin rash & increased risk of malignancy Dermatomyositis
Antibodies to U1RNP Mixed connective tissue disease
Dry eyes, dry mouth & arthritis Sjogren's syndrome
a/w rheumatoid arthritis & dental carries Sjogren's syndrome
Autoantibodies to SS-A(Ro) & SS-B(La) Sjogren's syndrome
Monosodium urate crystals Gout
Calcium pyrophosphate crystals Pseudogout
a/w elevated levels of ACE Sarcoidosis
Joint problem a/w uveitis & aortic regurgitation Ankylosing spondylitis
Triad of: Urethritis, Conjunctivitis & anterior uveitis, Arthritis Reiter's syndrome "Can't see, can't pee, can't climb a tree"
What is CREST syndrome Calcinosis, Raynaud's phenomenon, Esophageal dysmotility, Sclerodactyly & Telangiectasia
Dysplastic nevus is a precursor to what? Melanoma
Most common benign bone tumor Osteochondroma
Bone tumor w/ interlacing trabeculae of woven bone surrounded by osteoblasts; <2cm Osteoid osteoma
Bone tumor w/ interlacing trabeculae of woven bone surrounded by osteoblasts; >2cm Osteoblastoma
Bone tumor w/ "double bubble" or "soap bubble" appearance on x-ray Giant cell tumor
Bone tumor that is a cartilaginous neoplasm found in intramedullary bone of distal extremities Enchondroma
Most common primary malignant tumor of bone Multiple myeloma or Osteosarcoma depending on the source
Bone tumor w/ Codman's triangle on x-ray Osteosarcoma
Bone tumor w/ anaplastic small blue cells Ewing's sarcoma
Bone tumor w/ "Onion skin" appearance in bone Ewing's sarcoma
Bone tumor a/w t(11;22) Ewing's sarcoma
Malignant cartilaginous bone tumor Chondrosarcoma
Expansile glistening mass within the medullary cavity Chondrosarcoma
Bone tumor w/ peak incidence of 20-40 years old Giant cell tumor
Bone tumor that is most common in men <25 years old Osteochondroma
Bone tumor w/ peak incidence in men of 10-20 years old Osteosarcoma
Tumor caused by t(x;18) Synovial sarcoma
Bone tumor that is most common in boys <15 years old Ewing's sarcoma
Bone tumor that is most common in men 30-60 years old Chondrosarcoma
Vasculitis seen commonly in heavy smokers Beurger's disease
Vasculitis known as "pulesless disease" Takayasu's arteritis
Vasculitis that primarily affects asian females <40 years old Takayasu's arteritis
Vasculitis w/ unilateral headache, jaw claudication & impaired vision Temporal arteritis
Vasculitis a/w Hepatitis B Polyarteritis nodosa
Vasculitis that affects renal & visceral veins w/ lesions of different ages Polyarteritis nodosa
Triad of vasculitis, granulomas in lungs & airway, & glomerulonephritis Wegener's granulomatosis
Vasculitis that is an acute, self-limiting disease of infants/kids Kawasaki disease
Most common form of childhood systemic vasculitis Henoch-Schonlein purpura
Skin rash, arthralgia, intestinal hemorrhage, abdominal pain & melena in kids Henoch-Schonlein purpura
AV malformation in small vessels Telangiectasia
ANA Antinuclear antibody a/w SLE
Anti-dsDNA Anti double stranded DNA a/w SLE(more specific than ANA)
Anti-Smith a/w SLE (more specific than ANA)
Anti-histone a/w Drug-induced lupus
Anti-IgG aka Rheumatoid factor a/w Rheumatoid arthritis
C-ANCA Antineutrophil cytoplasmic Ab a/w Vasculitis
P-ANCA Antineutrophil cytoplasmic Ab a/w Vasculitis
Anticentromere a/w Scleroderma (CREST)
Anti-Scl-70 a/w Scleroderma (Diffuse)
Anti-epithelial cell a/w Pemphigus vulgaris
Anti-Jo-1 a/w Polymyositis & dermatomyositis
HLA a/w: Ankylosing spondylitis HLA-B27
HLA a/w: Reiter's Syndrome HLA-B27
HLA a/w: SLE HLA-DR2
HLA a/w: Rheumatoid Arthritis HLA-DR4
Created by: Asclepius