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USMLE
MSK Derm 1
| Question | Answer |
|---|---|
| What makes up the unhappy triad in a knee injury? | Damage to ACL, MCL & medial meniscus Caused by clipping from the lateral side |
| What are the rotator cuff muscles? | SITS Supraspinatus, Infraspinatus, Teres minor, Subscapularis |
| Failure of longitudinal bone growth leads to short limbs | Achondroplasia |
| Heberden's & Bouchard's nodes | Heberdon's-DIP; Bouchard's-PIP a/w osteoarthritis |
| Failure of normal bone resorption leads to thickened, dense bones | Osteopetrosis |
| "Brown tumors" | a/w Osteitis fibrosa cystica- caused by hyperparathyroidism |
| Abnormal bone architecture caused by increase in both osteoblastic & osteoclastic activity | Paget's disease of the bone |
| Bone is replaced by fibroblasts, collagen & irregular bony trabeculae | Polyostotic fibrous dysplasia |
| Joint problem a/w temporal arteritis | Polymyalgia rheumatica |
| Progressive symmetric proximal muscle weakness caused by CD8+ T-cell-induced injury to myofibers | Polymyositis |
| Polymyositis w/ "shawl & face" skin rash & increased risk of malignancy | Dermatomyositis |
| Antibodies to U1RNP | Mixed connective tissue disease |
| Dry eyes, dry mouth & arthritis | Sjogren's syndrome |
| a/w rheumatoid arthritis & dental carries | Sjogren's syndrome |
| Autoantibodies to SS-A(Ro) & SS-B(La) | Sjogren's syndrome |
| Monosodium urate crystals | Gout |
| Calcium pyrophosphate crystals | Pseudogout |
| a/w elevated levels of ACE | Sarcoidosis |
| Joint problem a/w uveitis & aortic regurgitation | Ankylosing spondylitis |
| Triad of: Urethritis, Conjunctivitis & anterior uveitis, Arthritis | Reiter's syndrome "Can't see, can't pee, can't climb a tree" |
| What is CREST syndrome | Calcinosis, Raynaud's phenomenon, Esophageal dysmotility, Sclerodactyly & Telangiectasia |
| Dysplastic nevus is a precursor to what? | Melanoma |
| Most common benign bone tumor | Osteochondroma |
| Bone tumor w/ interlacing trabeculae of woven bone surrounded by osteoblasts; <2cm | Osteoid osteoma |
| Bone tumor w/ interlacing trabeculae of woven bone surrounded by osteoblasts; >2cm | Osteoblastoma |
| Bone tumor w/ "double bubble" or "soap bubble" appearance on x-ray | Giant cell tumor |
| Bone tumor that is a cartilaginous neoplasm found in intramedullary bone of distal extremities | Enchondroma |
| Most common primary malignant tumor of bone | Multiple myeloma or Osteosarcoma depending on the source |
| Bone tumor w/ Codman's triangle on x-ray | Osteosarcoma |
| Bone tumor w/ anaplastic small blue cells | Ewing's sarcoma |
| Bone tumor w/ "Onion skin" appearance in bone | Ewing's sarcoma |
| Bone tumor a/w t(11;22) | Ewing's sarcoma |
| Malignant cartilaginous bone tumor | Chondrosarcoma |
| Expansile glistening mass within the medullary cavity | Chondrosarcoma |
| Bone tumor w/ peak incidence of 20-40 years old | Giant cell tumor |
| Bone tumor that is most common in men <25 years old | Osteochondroma |
| Bone tumor w/ peak incidence in men of 10-20 years old | Osteosarcoma |
| Tumor caused by t(x;18) | Synovial sarcoma |
| Bone tumor that is most common in boys <15 years old | Ewing's sarcoma |
| Bone tumor that is most common in men 30-60 years old | Chondrosarcoma |
| Vasculitis seen commonly in heavy smokers | Beurger's disease |
| Vasculitis known as "pulesless disease" | Takayasu's arteritis |
| Vasculitis that primarily affects asian females <40 years old | Takayasu's arteritis |
| Vasculitis w/ unilateral headache, jaw claudication & impaired vision | Temporal arteritis |
| Vasculitis a/w Hepatitis B | Polyarteritis nodosa |
| Vasculitis that affects renal & visceral veins w/ lesions of different ages | Polyarteritis nodosa |
| Triad of vasculitis, granulomas in lungs & airway, & glomerulonephritis | Wegener's granulomatosis |
| Vasculitis that is an acute, self-limiting disease of infants/kids | Kawasaki disease |
| Most common form of childhood systemic vasculitis | Henoch-Schonlein purpura |
| Skin rash, arthralgia, intestinal hemorrhage, abdominal pain & melena in kids | Henoch-Schonlein purpura |
| AV malformation in small vessels | Telangiectasia |
| ANA | Antinuclear antibody a/w SLE |
| Anti-dsDNA | Anti double stranded DNA a/w SLE(more specific than ANA) |
| Anti-Smith | a/w SLE (more specific than ANA) |
| Anti-histone | a/w Drug-induced lupus |
| Anti-IgG | aka Rheumatoid factor a/w Rheumatoid arthritis |
| C-ANCA | Antineutrophil cytoplasmic Ab a/w Vasculitis |
| P-ANCA | Antineutrophil cytoplasmic Ab a/w Vasculitis |
| Anticentromere | a/w Scleroderma (CREST) |
| Anti-Scl-70 | a/w Scleroderma (Diffuse) |
| Anti-epithelial cell | a/w Pemphigus vulgaris |
| Anti-Jo-1 | a/w Polymyositis & dermatomyositis |
| HLA a/w: Ankylosing spondylitis | HLA-B27 |
| HLA a/w: Reiter's Syndrome | HLA-B27 |
| HLA a/w: SLE | HLA-DR2 |
| HLA a/w: Rheumatoid Arthritis | HLA-DR4 |
Created by:
Asclepius
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