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Cell motility

TermDefinition
Cell locomotion Signals from soluble factors, other cells to the receptors on exposed on the plasma membrane. signal transduction pathway and to cytoskeleton. organisation, movement,contraction and shape of organelles
Why cell locomotion ? development, healing, protection and blood clotting
Polarity all moving cells
keratinocytes and fibroblast similar morphological changes
Steps Extension, adhesion, translocation,de-adhesion and endocytic cycle
Extension Cortical zone is highly active. Lamellipodium extends towards direction of movement
adhesion formation of new site of attachment at extended end of lamellipodium- adhesion plaques. integrin tightly bounds to the ecm at focal adhesion.
integrin proteins recognizing ecm component
translocation myosin dependent cortical contractions at the rear, squeeze nucleus and other organelles forward
de-adhesion and recycling detachment of the focal contacts. if its tightly bound some of the plasma membrane can be left behind. integrins are recycled.
Created by: purespirit
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