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Immuno

Diseases

QuestionAnswer
Multiple sclerosis Central Nervous System (oligodendrocytes);Demyelination
Acute Idiopathic Polyneuritis (Guillian-Barre syndrome) Peripheral nerves; Demyelination
Myasthenia gravis Neuromuscular junciton,Acetylcholine receptor; Impaired transmission
Hashimotos thyroiditis Thyroid (hypothyroidism);Anti-thyroglobulin, anti-thyroid epithelium
Grave's disease Thyroid (hyperthyroidism); Anti-TSH receptor
Goodpasture's Syndrome Basement membranes of renal glomeruli (and some pulmonary alveoli); Kidney/Respiratory failure
Addison's disease Adrenal glands; Anti-adrenal cell membranes and lymphocyte/monocyte cortical infiltration
Insulin-dependent diabetes mellitus Pancreatic islets (beta cells); Beta cell destruction
Sjogren's Syndrome Salivary glands; Glandular inflammation
Autoimmune hemolytic anemia Erythrocytes; Erythrocyte destructino and anemia
Thrombocytopenias Platelets or megakaryocytes; Platelet destruction/abnormal bleeding
Chronic atrophic gastritis; Pernicious anemia Gastic mucosal; Loss of gastric secretory function, Failure of vitamin B12 absorption due to loss of intrinsic factor or intrinsic factor producing cells
Intestinal granulomatous disease (Crohn's) Mucousal membrane of terminal ileum; Mucosal ulceration, obstructive granuloma
Rheumatic fever Heart; Myocarditis, Scarring of heart valves
Pemphigus vulgaris Epidermis; Blistering of the skin
Systemic lupus erythematosis Variety of organs; Numerous specificities of autoreactivity-Acute immune complex disease prominent
Rheumatoid arthritis Initially joints, spreading to cartilage bone and muscle; Immune complex disease in synovium, Anibodies (RF) against IgG prominent inflammatory T cells noted
Created by: Fernandezna
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