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IAV Immune evasion

Influneza virus A immune evasion mechanisms

QuestionAnswer
Function of RIG-I PRR - recognises PAMP dsRNA in cytoplasm Activates MAVs - downstream signalling cascade for activation of IFN type 1 (IFN beta)
NS1 function RIG-I sequesters dsRNA reducing activation of RIG-I binds to TRIM25 preventing essential ubiquination of RIG-I
NS1 function 2 binds to host nuclear complex preventing export of host mRNA from the nucleus
NS1 function 3 Prevents post translational modification of mRNAS specifically targeting mRNA with poly A tails.
NS1 function 4 May have a role in RNAi antagonisation, shown in insects not yet in mammalian cells
PB1-FA function binds to MAVs preventing down stream activation
IFITM Interferon induced transmembrane proteins -function to prevent endocytosis of viral envelope -patients with defective IFITM proteins more likely to be hospitalized with influenza
OAS 2'-5' oligodenylate synthetase -recognizes dsRNA -activates RNase L which degrades viral RNA -NS1 sequesters dsRNA reducing activation
PKR protein kinase R -phosphorylates eif2a preventing translation of mRNAs and induces apoptosis -NS1 binds to PKR causing a conformtational change inhibiting function -NS1 upregulates P58IPK host gene which is cellular inactivator of PKR
MAV mitochondrial antiviral signalling protein - signalling cascade activating IFN response
Created by: teemo616
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