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Colangiocarcinoma

câncer

QuestionAnswer
incidência 1/100000/ano nos EUA 87/100000/ano na Ásia e China
epidemiologia 15 a 25% dos tumores de fígado
fatores de risco Doença de Caroli Cistos coledocianos Clonorchis sinensis Colangite esclerosante Anastomoses bileodigestivas anteriores Colelitíase Thorotrast Colite ulcerativa Opisthorchis viverrini Asbestos Isoniazida Metildopa ACHO
tipos Adenocarcinoma (95%)
Localização Hilares (67%) Distais (27%) Intrahepáticos (6%) metástase em 75 -80% ao diagnóstico Pulmonar -10 a 15% Ósseas -10% SNC -2 a 3%
Manifestações clínicas Icterícia Prurido Dor abdominal Perda de peso Ascite Esplenomegalia * Sd de Klatskin: icterícia crescente, s/ colangite, hepatomegalia, VB vazia e sem hipoprotrombinemia universal
Estadiamento / Classificação TNM
Diagnóstico
Tratamento Paliação não-cirúrgica Stent -grande risco de contaminação
Prognóstico Sobrevida em 5 anos De 15 a 25% Intrahepático --> 30 -40% Perihilar --> 10 a 20% Distal --> 28 a 45 %
Created by: diegos
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