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Endocrine System - 2
endocrine system
What are the 2 product homormones of the Thyroid Gland? | 1. Thyroid Hormone 2. Calcitonin |
What are the two population of cells in the Thyroid Gland? | 1. Follicular Cells - produce Thyroid Hormone 2. Parafollicular or C cells - produce Calcitonin |
Follicular cells & production of thyroid hormone | Form central cavities where colloid is filled a fluid containg protiens make Thyroglobulin in the colloid iodide absorbed from GI Tract - cytoplasm attaches to tyrosine portion of thyroglobulin tyrosine molecules become linked & form thyroid hormone |
Two types of thyroid hormone/Effects (which is produced from Thyroid gland, other hormone - calcitonin) | T3 - 3 iodide atms T4 - 4 iodide atms They are Calorigenic - increase metab. rate, body temp, energy, promote breakdown of protien, lipid, carbs |
Thyroid hormone feedback | 1. Release of Thyroid releasing hormone TRH from Hyphothalmus 2. release of Thyroid stimulating hormone from Pituitary Gland |
C-cells/parafollicular cells & production of calcitonin | larger & squished between follicles involved in calcium homeostasis overproduction - lower bld calcium levels Inhibits osteoclast activity (slows release of calcium from bone) bone deposition of calcium (inhibits) calcium riding by the kidny |
Parathyroid glands (4) | posterior of thyroid gland Produce PTH(parathormone) calcium homeostasis...helps prevent hypocalcemia...removed=low blood calcium kidney & bone resorption, GI absorption |
RISE OF CALCIUM LEVELS IN BLOOD | 1. Thyroid gland produces calcitonin increased excretion of ca+ by kidneys calcium deposition in bone LOWERS SERUM CALCIUM |
DROP OF CALCIUM LEVELS IN BLOOD | 1. Parathyroid glands secrete parathyroid hormone (PTH) Increased reabsorption of by kidneys Calcium release from bone INCREASES SERUM CALCIUM |
Adrenal Gland & parts | Cap the kidneys 2 glands 2 sections: 1. Adrenal cortex (periphery) 2. Adrenal medulla (interior) |
What are the 3 regions of the Adrenal Cortex? Each produce specific steroid hormones | 1. Zona glomerulosa - closest to capsule 2. Zona fasciculata - middle zone, foamy appreance 3. Zona reticularis - closest to medulla |
Zona glomerulosa - Adrenal Cortex of Adrenal Gland | under capsule Produces mineralocorticoids (aldosterone) Regulates sodium resorption by kids in exchange for K+ |
Zona fasciculata - Adrenal Cortex of Adrenal Gland | Produces glucorticoids Effect on glucose metabolism Glucocorticoids : cortisol - [cortisone] in liver - corticosterone glucose formation, maintain blood p, resist stress |
Zona reticularis - Adrenal Cortex of Adrenal Gland | Closest to medulla Androges-sex hormones in small amounts |
Adrenal Medulla of Adrenal Gland produces what two hormones? | Interior - resembel nerve tissue 1. Epinephrine 2. Noreinephrine Under Symp Nervous System Control - last longer |
HYPERadrenocorticism | Cushing's syndrome & disease - weight gain, hairloss too much gluocorticids (fasciculata) |
HYPOadrenocorticism | Addison's disease, too little glucorticids (fasciculata) |
Feedback of Glucocorticoids feed back to what two locations: | 1. CRH - corticotropin releasing hormone from hypothalamus 2. ACTH - adrenocorticotropic hormone from anterior pituitary gland GLUCOCORTICOIDS HAD INHIBITORY EFFECTS ON TWO |
Pancrease - what are the two broad functions? | 1. Exocrine - digestive enzyme (most mass of pancrease) 2. Endocrine - hormones produced by "Islets of Langerhans) small nodules of tissue throughout pancreas) Products: Insulin (beta),Glucagon (alpha), Somatostatin (Delta), Pancreatic Polypeptide F cell |
What are the two group of cells in a pancreas? | 1. Islet cells - endocrine function 2. Acinar cells - exocrine function - produce digestive enzymes transported to duodenum via 2 ducts |
Islets of Langerhans & 4 population | Nests or groupings spred b/w acinar cells 1. Alpha cells 2. Beta cells 3. Delta cells 4. F Cells |
1. Alpha cells of Islets of Langerhans | secret glucagon increases blood glucose lvl by increasing release of glucose by liver |
2. Beta cells of Islets of Langerhans | secret insulin decreases blood glucose by increasing body cell uptake & utilization of glucose |
3. Delta cells of Islets of Langerhans | produce like growth hormone inhibiting somatostatin suppresses release of insulin & glucose from other Islet cells |
4. F cells of Islets of Langerhans | produce pancreatic polypeptide (PP) inhibit gall bladder contraction |
Diabetes Mellitus | insulin deficiency |
What does Insulin do? | cause glucose in the blood to be absorbed into cells utilization of glucose |
What does Glucagon do? | causes bld lvl of glucose to rise deficiency is not ofter critical |
RISE IN GLUCOSE | causes insulin release normalize |
DROP IN GLUCOSE | causes glucagon release |
Testes | interstitial cells produce & release androgens stimulated by LH from pituitary Primary product/androgen - testosterone stimulation of bone & muscle build up |
Ovaries | production of estrogens & progestins Stimulated by FSH & LH from pituitary estrogens cause behavorial & phy changes Progestins help maintain pregnancy if needed |
Kidneys - what three hormones are released? | 1. Calcitriol 2. Erythropoietin 3. Renin |
Hormones of Kidney - 1. Calcitriol | steriod hormone released by Kidney release stimulated by PTH raises blood calcium (PTH raises ca lvl by causing calcitriol release) |
Cholecalciferol (vit D3) | converted to calcitriol related steroid produced in skin/absorbed in Tract |
Hormones of Kidney - 2. Erythopoietin | EPO release stimulated by low oxygen in Kidney tiss stimulates bone marrow production of RBCs deficiency - kidney failure - anemia due to low production of hormone |
Hormones of Kidney - 3. Renin | Enzyme Stimulus for release: 1. sympathetic stimulation 2. Decreased renal blood flow starts seq. that results in angiotensin 2(whcih stims release of Aldosterone &ADH) potent vasoconstrictor, pools bld centraly |
GI Tract | produce gastrin stimulates gastric gland to release HCl & enzymes stimulaltes gastric motility |
Small Intestine | secretin - stim pancrease to produce buffering fluid CCK - stim pancreas to release digestize enzyme & gall bladder contraction |
Placenta | produce estrogen, progestins, chorionic, gonadotropin - help maintain pregnancy |
Thymus | atrophy maturation of immune system matures cells to Tlymphs, crucial for immune responses |
Pineal Body | part of brain cyclic production of melatonin which affects sleep cucles |
Prostaglandins | derived from fatty acids - initiate inflamation |