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CANCER BIOLOGY

TRANSCRIPTION PART 2

QuestionAnswer
SPLICING -REMOVES INTRONS FROM THE TRANSCRIPT (mRNA) & LINKS THE REMAINING EXONS TOGETHER IN A EUKARYOTIC CELL (CUT AND PASTE JOB)
CAPPING ENZYME COMPLEX -ATTACHES A GTP MOLECULE TO THE 5' END OF THE 5' G-CAP DURING TRANSCRIPTION IN THE NUCLEUS -5'CAP PREVENTS PREMATURE mRNA DEGRADATION
POLYADENLYATE POLYMERASE -ATTACHES 50-250 ADENINE NUCLEOTIDES TO THE 3' mRNA END TO FORM THE POLY-A-TAIL -POLY-A-TAIL PREVENTS PREMATURE mRNA DEGREDATION
SPLICEOSOME -REMOVES INTRONS FROM THE mRNA AND SPLICES (LINKS) THE REMAINING EXONS TOGETHER -SMALL NUCLEAR RIBONUCLEOPROTEIN (SNURPS) -SOME INTRONS REMOVE THEMSELVES B/C THEY ARE RIBOZYMES
ALTERNATIVE SPLICING -ENABLES ONE GENE TO PRODUCE DIFFERENT VERSIONS OF THE PROTEIN IT ENCODES -EACH VERSION IS SPECIALIZED FOR A SPECIFIC CELL TYPE, SPECIFIC STAGE OF DEVELOPEMENT, OR SPECIFIC ENVIRONMENTAL CONDITION
ABNORMAL SPLICING OF mRNA TRANSCRIBED FROM A PROTO-ONCOGENE CAN INCREASE THE RISK OF CANCER
B-THALASSEMIA (~1 IN 100,000) IS DUE TO IMPROPER SPLICING OF THE B-GLOBIN mRNA -MALARIA RESISTANCE -FEWER RED BLOOD CELLS THAT CONTAIN B-GLOBIN LEVELS -BLOOD TRANSFUSION REQUIRED EVERY 2 WEEKS
Created by: dgira002
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