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CANCER BIOLOGY

TYPES OF TUMORS AND TREATMENTS

QuestionAnswer
CANCER PRESENTS... A DIFFICULT SET OF PROBLEMS BECAUSE CELL IN A SINGLE TUMOR CAN HAVE DIFFERENT GENOTYPES AND RESPOND DIFFERENTLY TO A SINGLE TREATMENT.
CHARACTERISTICS OF CANCER (5) ABNORMAL BINDING TO CELL/ECM INDEFINITE DIVISION APOPTOSIS IS COMPROMISED INCREASED LIFESPAN (ABNORMAL AGING) UNREGULATED CELL CYCLE
MALIGNANT TUMORS ARE... A SOURCE OF CANCER CELLS THAT CAN METASTASIZE (MOVE=MALIGNANT)
TAXOL/ VINCA ALKALOIDS FUNCTIONS (3)... BIND TO SPINDLE MICROTUBULES DISRUPT SPINDLE FUNCTION INDUCE APOPTOSIS (BID)
METHOTREXATE -INHIBITS ENZYME DIHYDROFOLATE REDUCTASE, TO PREVENT THYMINE (dTTP) SYNTHESIS -INHIBITS PURINE SYNTHESIS
ANTI-HORMONE THERAPY DEPRIVES SOME BREAST, ENDOMETRIAL, AND PROSTRATE CANCER CELLS OF THEIR GO-SIGNAL WHICH ACTIVATES THE G1 CHECKPOINT RESULTING IN APOPTOSIS -PREVENTS HORMONE FROM BINDING TO RECEPTOR EX:ANTI-ANDROGEN & ANTI0ESTROGENS
ANTIBODY THERAPY HERCEPTIN ONLY APPROVED BINDS TO TUMOR CELLS AND FLAG THEM FOR DESTRUCTION BY THE IMMUNE SYSTEM
ANGIOGENESIS INHIBITION -PROCESS OF NEW BLOOD VESSEL FORMATION -POTENTIAL TREATMENT FOR METASTATIC CANCER IS ANGIOSTATIN (LADY W/HUGE TUMOR ON BACK)
METABOLIC PROFILING IDS COMPOUNDS IN CANCER CELLS THAT ARE TARGETS FOR CHEMOTHERAPY -GLYCINE PERFORMS ESSENTIAL METABOLIC FUNCTIONS IN CANCER CELLS -DRUGS ARE BEING DEVELOPED TO INHIBIT GLYCINE SYNTHESIS/GLYCINE IMPORT INTO CANCER CELLS
NANOPARTICLE THERAPY -SOLUBLE BLOOD/LYMPH -LOCATE/ID ALL CANCER CELLS IN BODY -AVOID DETECTION BY IMMUNE SYSTEM & REMOVAL BY LIVER/KIDNEYS -DELIVER DRUGS TO CANCER CELLS & NEVER TO HEALTHY CELLS (SLAD)
GARADASIL TRAINS THE ACQUIRES IMMUNE SYSTEM TO RECOGNIZE SOME HPV SURFACE PROTEINS -PREVENTS CERVICAL CANCER DEVELOPMENT BUT DOESN'T CURE IT. (HPV VAC)
RADIATION THERAPY CAUSES... -SUBSTANTIAL MUTATIONS THAT ACTIVATE THE DNA DAMAGE CHECKPOINT TO INDUCE APOPTOSIS -CANCER CELL LACKS SOME DNA REPAIR ENZYMES
Created by: dgira002
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