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Day 4a

Part II - Known Teratogenes Drugs

QuestionAnswer
Methyltestosterone (Androgens) - 1st Trimester
Danazol (Androgens) - 1st Trimester
Nandrolone (Androgens) - 1st Trimester
Oxandrolone (Androgens) - 1st Trimester
Phenytoin (Anticonvulsants) - 1st Trimester
Carbamazepine (Anticonvulsants) - 1st Trimester
Valproic Acid (Anticonvulsants) - 1st Trimester
Phenobarbital (Anticonvulsants) - 1st Trimester
Lamotrigine (Anticonvulsants) - 1st Trimester
What associated primarily with neural tube defects? What to treat? Anticonsulsants (Carbamazepine and Valproate) - Folic acid 4mg/d
Busulfant (Chemotherapy) 1st Trimester
Chlorambucil (Chemotherapy) 1st Trimester
Cyclophosphamide (Chemotherapy) 1st Trimester
Cytarabine (Chemotherapy) 1st Trimester
Methotrexate (Chemotherapy) 1st Trimester
5-fluorouracil (Chemotherapy) 1st Trimester
cis-retinoic acid (Chemotherapy) 1st Trimester
Lithium 1st Trimester
Associated with cardiac defects (dose related) Lithium
Coumarin derivaties (Warfarin) 1st, 2nd, and 3rd trimester
Spontaneous abortion, stillbirth, neonatal death, cns abnormalities Warfarin
Isotretinoin (Accutane) (1st trimester) Retinoid derivatives
Acitretin (Soriatane) (1st trimester) Retinoid derivatives
Risk of Isotretinoin (Accutane) Structural abnormalities and Mental retardation
HMG CoA reductase inhibitors (1st trimester) - Structural defectives
ACE Inhibots (2nd and 3rd trimesters)
NASIADS (2nd and 3rd trimesters)
Tetracyclines (2nd and 3rd trimesters)
Reduced fetal renal blood flow ACEi
Closure the ductus resulting in pulmonary hepertension NSAIDS
Tooth discoloration and inhibition or bone growth Tetracyclines
Iodine/thyroid medications All trimesters or period unknown
Streptomycin (All trimesters or period unknown) - Aminoglycosides
Kanamycin (All trimesters or period unknown) - Aminoglycosides
Fetal ototoxicity Aminoglycosides
SSRI (All trimesters or period unknown)
Low birth weight and /or respiratory distress SSRI
Misoprostol (cytotec) (All trimesters or period unknown) -
Associated with abortion, congenital malformations, premature labor Misoprostol (Cytotec)
Thalidomide (All trimesters or period unknown)
STEPS program - a high association with structural defects Thalidomide
Ergotamine (All trimesters or period unknown) - Ergot derivatives
Caffergot (All trimesters or period unknown)- Ergot derivatives
Dihydroergotamine (All trimesters or period unknown)- Ergot derivatives
Constric uterine blood vessels thereby affecting placental blood flow = low birth weight Ergot derivatives
Vitamin A Teratogens with confluict data (<5000 U/d is safe), >25000 = birth defect
ASA Teratogens with confluict data - High dose (>325)
Benzodiazepines Teratogens with confluict data - Hypotonia (ypotonia, hypothermia, respiratory depression)
Certain estrogens and progestins Teratogens with confluict data
Beta blockers Teratogens with confluict data
Claravis (Retinoid Derivatives) - Isotretinoin (Accutaine) -- 1st Trimester
Amnesteen (Retinoid Derivatives) - Isotretinoin (Accutaine) -- 1st Trimester
Sotret (Retinoid Derivatives) - Isotretinoin (Accutaine) -- 1st Trimester
Effect during organogenesis Chemetherapy agents - 1st Trimester
Created by: _Tom_
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