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Tumor Progression
| Question | Answer |
|---|---|
| How does tumor spread? | epitheliel cells join by E-cadherins. ITs downregulation causes cells to attach to laminin secrete collagenase- destroy collagen4 of BM. Attach to fibronectin to spread in EM. Then go to lymph of Blood. |
| If tumor spreads to lymph, then the type of tumor is called? | Carcinoma produced. eg breast cancer |
| if tumor goes to blood, then the type of tumor is called? | characteristic of sarcomas and some carcinomas. 1. Renal cell carcinoma (often invades renal vein) 2. Hepatocellular carcinoma (often invades hepatic vein) 3. Foll icular carcinoma of the thyroid 4. Choriocarcinoma |
| if tumor goes to body cavities , then the type of tumor is called? | Seeding of body cavities is characteristic of ovarian carcinoma, which often involves the peritoneum |