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med immunology 13
Complement
| Question | Answer |
|---|---|
| complement system is a set of _____________ designated numerically according to the order of their _______. | serum proteins, discovery |
| complement activation results in ______ of the foreign cell or infected cells. | lysis |
| There are 3 major ways to activate complement system. List those. | classical pathway, alternative pathway, lectin pathway |
| Which complement activation pathway is this: fast acting, uses antibody. | classical pathway |
| Which complement activation pathway is this:slow acting, does not use antibody. | alternative pathway |
| Which complement activation pathway is this: use the antigen. | lectin pathway |
| In classical pathway, various complement proteins act ____________ to "complement" the action of antibodies. | nonspecifically |
| What initiates classical complement pathway? | C1 |
| Fragment of C5b combines with several molecules to form _____________, which drills a cytoplasmic membrane of pathogen. | membrane attack complex (MAC) |
| _____ is very important complement protein because the its fragment becomes enzyme to split C5 for forming MAC or act as opsonin or cause chemotaxis and inflammation | C3 |
| In alternative pathway, activation occurs without ________. Instead of those, the activation is made by _______ complement protein. | antibodies, C3b |
| Because alternative pathway is independent of antibodies for activation, it is useful in _______ of infection. | early stages before antibodies have been made |
| Complement proteins consists of ______ _______ that work in concert to destroy bacteria and viruses. | 26 blood proteins |
| Complement proteins work in concert to destroy ______ and ______. | bacteria, viruses |
| Complement proteins are activated by ________ using enzymes | cleavage |
| All three complement pathways cleave complement protein _______, and the fragments becomes enzyme to cleave _______. | C3, C5 |
| 3 main function of complement system are _________, __________, and __________. | opsonization, inflammation, killing of pathogen(cell lysis) |
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