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med immunology 10

activation and function of T and B cells

QuestionAnswer
Which cells are the primary APCs that activate uncommitted/native CD4+T cells? dendritic cells
_______ is the term used to describe the contact between the APC and the naive CD4+T cell. immunogenic synapse
After APC and CD4+T cells interact, what will happen? proliferation, produce & release cytokines, differentiation of T cell into effector cells, effector cells migrate to lymph nodes of invaded site
What events occur in the intracellular chemical pathway after CD4+T cell are activated? activation of kinase by phosphorylation and kinase activates transcription factor Nf-kB, activation of intracellular signaling pathways and ligands, activation of several transcription factors involved in CD+T cell production and synthesis of cytokines
How CD8+T cells are activated? directly by dendritic cells, dendritics cells with CD4+T cells (direct and mediation)
How CD8+T cells kill the infected cells? breaking down, forcing apoptosis.
How CD8+T cells force infected cells apoptosis? by locking their Fas ligand receptor into the Fas molecule on the host cell
How B cells can be activated? by type2 helper T cells with APC, directly if antigens are polysaccharide
To activate B cells, mainly which kind of APC is in chrage? macrophage (activated monocyte)
polysaccharide antigens which can directly activate B cells are called __________. Thymus independent
The antibody produced by B cells which are activated by thymus independent antigen is _______. IgM
When B cells are activated by polysacchaide antigen directly and T-cells are not involved in the activation, there is _________developed for such antigens. no memory
What is superantigens? bacterial toxins produced by bacterial pathogens such as Staphylococcus aureus.
What symptoms are caused by supreantigens? hemolysis, exfoliation, shock and hood poisoning
As a result of the activation and proliferation of CD4+T cells, 4 subsets of CD4+T cells can be produced. _______ act on macrophages, NK cells, CD8+T cells, and make B cells secrete IgG3 TH1
As a result of the activation and proliferation of CD4+T cells, 4 subsets of CD4+T cells can be produced. ______ act on eosinophils and make B cells secrete IgE and IgG4. TH2
As a result of the activation and proliferation of CD4+T cells, 4 subsets of CD4+T cells can be produced. ______ activate neutrophils, epithelial cells and lead to responses to fungi and bacteria. TH17
As a result of the activation and proliferation of CD4+T cells, 4 subsets of CD4+T cells can be produced. ______ inhibits function of other sets of T cells and non-T cells. Treg
Created by: hiroko lucky2
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