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med immunology 7
| Question | Answer |
|---|---|
| Where does B cell begin it differentiation and development? | bone marrow |
| What do mark the differentiation and developmental stages of B cell? | the presence of various CD molecules |
| What is CD? | Clusters of differentiation |
| Each stage of differentiation and development of B-cell displays _______________. | specific CD molecules |
| What is called the earliest precursor B cell that is achieved by the rearrangement of DH and JH? | Pro-B cell |
| What is called the stage that is achieved by the rearrangement of VH and DJ? | Pre-B cell |
| During Pre-B cell stage, what gene comes in contact with VDJ? | C-mu |
| What is C-mu? | responsible to form Constant chain |
| After Pre-B cells are formed, what is formed with several receptor molecules? | Pre-B cell receptor complex |
| List 3 of Pre-B cell receptor complex | surrogate light chains, signal transduction molecules Ig alpha and Ig Beta |
| By the end of Pre-B-cell stage, which antibody is produced on B-cell surface? | IgM |
| IgM forms an association with _______ | Ig alpha and Ig beta |
| If the immature B cell interacts with cell-bound self antigen, what will happen? | receptor editing |
| If the immature B cells is still reactive to cell bound self antigen after receptor editing, what will happen? | colonal deletion |
| If the immature B cells developed receptor for non-self antigen, what will happen? | they can be rescued |
| If the immature B cells are exposed to soluble self antigen in the bone marrow, what will happen? | anergy |
| what is anergy? | long term inactivation |
| how you can tell the B cell is matured? | if it has IgM and IgD on the surface |
| What leads to activation and production of plasma cells to secrete antibodies? | exposure to foreighn antigen |
| How memory B cells produce different types of Ab other than IgM? | By class switching during the secondary response |
| From what do thymus dependent foreign antigens solicit help to stimulate B cells to make antibodies? | helper T cells |
| In the beginning of B and T cell cooperation, which ab is produced? | IgM |
| What is called where T and B cell cooperation, somatic hypermutation, class switching occur after B cell left the bone marrow? | germinal centers of second lymphoid organs |
| What is going on in the germinal center? | somatic hypermutation, class switch recombination, T and B cells cooperation. |
| How class switching occur in germinal center? | by the influence of cytokines such as IL2 |
| B cells that are activated in the lymph organs develop into _______ and ______. | plasma cells, memory B cells |
| Where memory B cells migrate? | different tissues and organs within the body for anamnestic response |
| Where plasma celss migrate? | bone marrow to continue making antibodies for a long time |
| List some examples of surface molecules which mature B cells express on the surface | MHC class 2, costimulatory molecules B7, CD40 |
| ______ _________ to produce more antibody diversity, _____ ______ _________ to produce different isotypes | somatic hypermutation, class switch recombination |
| class switching of isotypes is under the influence of _________ released by T cells. | cytokines |
| Where is germinal centers? | second lymphoid organs |
Created by:
hiroko lucky2
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