NURS 572 Ch 73 gout Word Scramble
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Question | Answer |
gout is usually, but not always characterized by | hyperuricemia |
acute episodes are ALWAYS characterized by | urate crystals in joint fluid |
what causes hyperuricemia/urate crystals | excessive production of uric acid-----impaired renal excretion of uric acid |
Acute tx of gout includes tx for pain, inflammation using these 3 classes of drugs | anti-inflam/cholchicine----NSAIDs---corticosteroids |
PREVENTION of gout bwo 2 mechanisms | decrease prodcution of uric acid---increase excretion (uricosuric) |
anti-inflamm agent to treat ACUTE gouty attack while offering some bridging to prevent subsequent attack | colchicine - oral |
We only give colchicine for 2 doses - why | wicked GI SEs n/v/DIARRHEA----rare nephrotoxicity |
name 2 drugs that are for chronic use/preventative ---lower uric acid levels | allopurinol---febuxostat |
MOA of drugs to lower uric acid = allopurinol, febuxostat | inhibit xanthine oxidase so it can't convert purines to uric acid |
are drugs to lower uric acid preventative? | yes, if there's less uric acid, then we are preventing goit |
why don't we use febuxostat as often | $$$ but it works same as allopurinol |
ADRs allopurinol | gen well tolerated-----Rare----hypersensitivity syndrome = rash/fever/eosinophilia/liver/kidney dysfunciton----cataracts-----GI,HA |
ADRs febuxostat | same as allopurinol except no dermatological hypersensitivity |
name 2 uricosurics that increase urinary excretion of uric acid | probenecid-----sulfinpyrazone |
why use uricosurics | only for PREVENTION of attacks----NO BENEFIT for acute gouty attack |
ADRs/class of probenecid and sulfinpyrazone | uricosurics with these ADRs---risk of nephrolithiasis---PT MUST DRINK 2-3 LITERS OF WATER PER DAY ---GI---hypersensitivity reactions |
Created by:
lorrelaws
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