NURS 572 Pharm 32 Word Scramble
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Question | Answer |
simplified MOA depression | lack of monamines Ser, Nor |
3 classes of antidepressants | TCA, SSRIs, atypicals |
MOA of TCAs | has structure similar to phenothiazine --> similar SEs of blocking H-1, Alpha-1 and muscarinic. IS A NONSELECTIVE blocker of Nor and 5HT serotonin |
MOA SSRI | selectively blocks 5HT serotonin |
MOA atypical antidepressants | mixed 5HT/NE reuptake inhibitor |
TCA general properties | high ind variability, 1-3 week response, 1-2 month max effect. long half like |
TCA SEs | cardiotoxic (combo direct cardiac effect, anticholinergic effect) . . . orthostatic, sedation, paradoxical diaphoriesis, seizures, hypomania |
name 4 TCAs | imipramine, amitriptyline, desipramine, protriptyline |
TCA moderately sedating | imipramine |
TCA VERY sedating, MANY SEs | amitriptyline |
TCA few SEs | desipramine |
TCA NOT sedating | protriptyline |
Major uses SSRI | major depressive, OCD, GAD, PMDD, PTSD, bulimia, panic, social phobia |
do SSRI's have orthostatic, sedative, anticholinergic, cardiotoxic SEs | no - they ONLY selectively inhibit 5HT. Most are highly protein bound, long acting, CYP450 metabolism |
common SSRIs SEs | compliance limiting sexual dys, N/D, HA, CNS stimulation, sweating |
What is important dosing SSRI | must taper off to avoid serotonin syndrome |
what is serotonin syndrome | too much ser --> conf, disorientation, hallucinations, incoordination, sweat, tremore, dysphoria |
S/S of serotonin withdrawal syndrome | anxiety, dizz, HA, N, tremor, dysphoria |
name 6 SSRIs | citalopram, escitalopram, fluoxetine, fuvoxamine, poxetine, sertraline |
SSRI with fewest interactions (2) | citalopram, escitalopram |
SSRI with longer half-lives (2) | fluoxetine, sertraline |
SSRI with relatively short action | paroxetine |
SSRI specific for OCD, shortest half-life | fluvoxamine |
atypical, also for smoking cessation | bupropion |
atypical, hepatotoxic | nefazodone |
atypical, more effective than SSRIs, dose related HTN significance | venlafaxine |
atypical, related to loxapine for added neuroleptic action (schizo & depression) | amoxapine, which has SEs of EPS, TD, anticholingergic, sedations and seizures all possible SEs |
atypical, VERY sedating, reported priapism | trazodone |
atypical SNRI, CNS and GI SEs | duloxetine |
Created by:
lorrelaws
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