Help
Options
Didn't know it?
click below
click below
Knew it?
click below
click below
Don't Know
Remaining cards (0)
Know
retry
shuffle
restart
0:00
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.
Normal Size Small Size show me how
Normal Size Small Size show me how
NURS 572 Pharm 32
Ch 32 Antidepressants
| Question | Answer |
|---|---|
| simplified MOA depression | lack of monamines Ser, Nor |
| 3 classes of antidepressants | TCA, SSRIs, atypicals |
| MOA of TCAs | has structure similar to phenothiazine --> similar SEs of blocking H-1, Alpha-1 and muscarinic. IS A NONSELECTIVE blocker of Nor and 5HT serotonin |
| MOA SSRI | selectively blocks 5HT serotonin |
| MOA atypical antidepressants | mixed 5HT/NE reuptake inhibitor |
| TCA general properties | high ind variability, 1-3 week response, 1-2 month max effect. long half like |
| TCA SEs | cardiotoxic (combo direct cardiac effect, anticholinergic effect) . . . orthostatic, sedation, paradoxical diaphoriesis, seizures, hypomania |
| name 4 TCAs | imipramine, amitriptyline, desipramine, protriptyline |
| TCA moderately sedating | imipramine |
| TCA VERY sedating, MANY SEs | amitriptyline |
| TCA few SEs | desipramine |
| TCA NOT sedating | protriptyline |
| Major uses SSRI | major depressive, OCD, GAD, PMDD, PTSD, bulimia, panic, social phobia |
| do SSRI's have orthostatic, sedative, anticholinergic, cardiotoxic SEs | no - they ONLY selectively inhibit 5HT. Most are highly protein bound, long acting, CYP450 metabolism |
| common SSRIs SEs | compliance limiting sexual dys, N/D, HA, CNS stimulation, sweating |
| What is important dosing SSRI | must taper off to avoid serotonin syndrome |
| what is serotonin syndrome | too much ser --> conf, disorientation, hallucinations, incoordination, sweat, tremore, dysphoria |
| S/S of serotonin withdrawal syndrome | anxiety, dizz, HA, N, tremor, dysphoria |
| name 6 SSRIs | citalopram, escitalopram, fluoxetine, fuvoxamine, poxetine, sertraline |
| SSRI with fewest interactions (2) | citalopram, escitalopram |
| SSRI with longer half-lives (2) | fluoxetine, sertraline |
| SSRI with relatively short action | paroxetine |
| SSRI specific for OCD, shortest half-life | fluvoxamine |
| atypical, also for smoking cessation | bupropion |
| atypical, hepatotoxic | nefazodone |
| atypical, more effective than SSRIs, dose related HTN significance | venlafaxine |
| atypical, related to loxapine for added neuroleptic action (schizo & depression) | amoxapine, which has SEs of EPS, TD, anticholingergic, sedations and seizures all possible SEs |
| atypical, VERY sedating, reported priapism | trazodone |
| atypical SNRI, CNS and GI SEs | duloxetine |
Created by:
lorrelaws
Popular Nursing sets