NURS 572 -55 Word Scramble
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Question | Answer |
hematopoietic growth factors treat for | RBC, WBC |
thrombopoietic growth factors treat for | platelets |
how must all hematopoietic growth factors be admin | parentarally |
epoetin-alpha MOA | recomb DNA --> RBC production. Need essential Fe, Folic Acit, Vit B12 |
indications for epoetin-alpha | chronic renal failure, HIV +, chemorx pts, anemic pts facing surgery |
Epoetin-alpha ADRs | HTN (increased Hgb) --> MI, CVA, HF very rare autoimmune red cell aplasia |
epoetin-alph monitoring | Hgb should be 10-12 g/dL, monitor bp q 4. May require anti-HTN med |
Darbepoetin-alpha | modified epoetin for double the half-life of 48 hours |
Methoxypolyethylene glcol epoetin-beta | modified epoetin lasting much longer, q2 week admin |
Filgrastim-G-CSF full name | filgrastim granulocyte colony stimulating factor |
filgrastim-G-CSF indications | to elevate neutrophil counts in cancer pts EXCEPT myeloid cancers |
Filgrastim - G - CSF ADRs | bone pain, leukocytosis (increases to 100,000) |
filgrasti - G - CSF monitoring | monitor CBC, temp, infection, bone pain |
Pegfilgrastim | peglated with polyethylene glycol to increase half life, otherwise same as filgrastim |
sargramostin GM-CSF full name | granulocyte + macrophage/monocyte colony stimulating factor |
Sargramostin GM CSF indications | bone marrow transplant pts, to increase neutrophils, macrophages/monocytes |
sargramostin GM CSF ADRs | diarrhea, weakness, rash, bone pain, leukocytosis and/or thrombocytosis |
oprelveken IL-11 full name | oprelvekin interleukin-11 |
oprelvekin IL-11 MOA | thrombopoietic growth factor stimulates megakaryocytes and maturation |
oprelvekin IL-11 indications | for myelosuppresive chemorx to minimize thrombocytopenia, decreasing the need for platelet transfusion |
oprelvekin IL-11 ADRs #1 | Na/fluid retention --> 15% increase in plasma volume --> peripheral edema --> HF |
oprelvekin IL-11 ADRs #2 | cardiac dysrthythmias, blurred vision, papilledema, rarely death |
Created by:
lorrelaws
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