CLI's Sem 2 Ex 1 Word Scramble
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Question | Answer |
ssRNA +ve stranded icosahedral, spherical virus, non-enveloped | Norovirus |
watery diarrhea, shortened intestinal villi, loss of digestive enzymes. Dx | Norovirus |
Norovirus uses what enzyme first to replicate? | RNA-dependant RNA polymerase. |
HIV enveloped or not? | enveloped |
HIV ss or ds? | ss and diploid |
HIV RNA or DNA? | RNA |
HIV shape and capsid? | spherical and icosahedral |
HIV + or – sense? | + sense (I’m HIV+) |
What does HIV bind to enter cell? | CD4 cell surface receptor and co-receptors |
4 cell types that HIV invades? | CD4+ helper T, monos, dendritic cells, and macrophages |
What do you detect to Dx HIV? And to follow it? | HIV antibodies, proviral DNA, and p24 antigen. Follow HIV-1 RNA load |
Where do you see HIV-2? | Africa |
What enzyme does HIV use for replication, first? | RNA-dependant DNA polymerase **reverse transcriptase. |
3 HIV viral genes for structural proteins | gag, pol, env |
Very small gram negative Hard to culture, mainly Dx by serology | Rickettsiae |
Likes endothelial cells, needs ATP, CoA, and NAD | Rickettsiae |
Rickettseae Tx | Tetra-, Doxy-cyclin, chloramphenicol |
Rickettseae transmitted by | tick, flea, mite, lice |
Person drinks contaminated milk, develops diarrhea, gram negative gull shaped rod is isolated. Is the organism motile? | yes, polar flagellum |
What do C.jejuni colonies look like on agar? | water droplettes |
Special needs to grow C.Jejuni | enriched media, 10%O2, 42*C x 24-72hr |
Can C.jejuni invade gut mucosa? | yes |
Anaerobic Pleomorphic gram – rod/coccobacilli, non-motile, non-spore forming | B.fragilis |
B. fragilis special culture needs | 48hr at 35* grown on blood agar or other anaerobic media |
Specimen grows on anaerobic media, giving off a foul smell, produces acetate and succinate | b.fragilis |
Transmitted endogenously from normal gut flora | B. Fragilis |
Causes Lyme disease | Borelia Burgdorferi |
Causes relapsing fever | Borrelia Recurrentis |
Bit by tick, with erythema chronicum migrans erupts Cause? | B. burgdorferi |
Bit by lice, fever waxes and wanes Cause? | B. recurrentis |
Stains used to see Borrelia under light microscope | Giemsa or acridine orange |
Common cause of BV | Gardnerella Vaginalis |
Gram variable rod, facultatively anaerobic, needs increased CO2 to grow | G. vaginalis |
Clue cells, with positive whiff test after KOH | G. Vaginalis |
From bird droppings, hyphae in soil, spores in haled, yeast in body | Histoplasma |
Dx: Culture on SDA with yeast cells in sputum or lungs | Histoplasma |
Coiled larva in muscle biopsy, diarrhea, muscle aches, Pt makes own smoked ham | T. spiralis |
2-3 nm roundworm | Trichinella Spiralis |
Pt had brain surgery 30 years ago in Botswana (?), develops neuro Sxs, dies, intracellular vacuoles found in brain on autopsy. Cause | CJD |
Becca’s BF from the UK develops neurological Sxs as well as everyone in his family who ate the same beef strokemeoff. Dx? | vCJD from bovine spongiform encephalopathy |
Pathogenesis of prion disease. What does is do? | Deposits altered host-protein |
90yo Papua New Guinea warrior w/ neurological Sxs, keeps smiling/laughing and shaking. Dx | Kuru |
Created by:
csheck
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