Chapter 13 Word Scramble
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Question | Answer |
Class of agents called________, all involved in neurotransmission | Catecholamines |
Natural catecholamines: | NE, epinephrine (adrenalin), dopamine |
Synthetic catecholamines: | Isoproterenol, dobutamine |
Adrenergic receptors: | Receptors at the ends of postganglionic sympathetic neurons that cause adrenaline-like response |
Stimulation of sympathetic nervous system is called? | Adrenergic agents or sympathomimetics |
Inhibition of sympathetic nervous system is called? | Adrenergic-blocking agents, adrenergic antagonists, or sympatholytics |
What are two Types of Adrenergic Receptors? | Alpha receptors and beta receptors |
Alpha 1 receptors location: | Eyes Arterioles (skin viscera, mucous membranes) Veins Sex organs (male) Bladder neck & prostatic capsule |
Alpha 1 receptor Response to Receptor Activation: | Eyes: mydriasis, Arterioles (skin viscera, mucous membranes): constrict, Veins: constrict, Sex organs (male): ejaculation, Bladder neck & prostatic capsule: contraction |
Beta 1 receptors location: | Heart & Kidney |
Beta 1 receptors response to receptor activation: | ↑HR, force of contraction & AV conduction velocity Renin release – RAS |
Beta 2 receptors location: | Arterioles (heart/ lungs/ skeletal muscle) Bronchi Uterus Liver Skeletal muscle |
Beta 2 receptors response to receptor activation: | Arterioles (heart/ lungs/ skeletal muscle): dilation Bronchi: dilation Uterus: relaxation Liver: glycogenolysis Skeletal muscle: Enhanced contraction, glycogenlysis |
Where are Alpha1- adrenergic Receptors found? | In all sympathetic target organs except heart |
What response do Alpha1- adrenergic Receptor produce in the body? | Constriction of blood vessels. Dilation of pupils |
Where are Alpha2- adrenergic Receptors found? | At presynaptic adrenergic neuron terminals |
What do Alpha2-adrenergic Receptors inhibit? | Inhibit release of norepinephrine |
Beta2- adrenergic Receptors are found in? | In all sympathetic target organs except the heart |
Beta2- adrenergic Receptors inhibit? | Inhibit smooth muscle |
What should be monitored in Adrenergic Drugs (Sympathomimetics)? | Vital signs, urinary and cardiac output as appropriate. Monitor breathing patterns. Observe patient's responsiveness to light. Monitor for rhinorrhea and epistaxis. |
Primary use of beta blockers is in the treatment of ? | Hypertension |
Beta- adrenergic antagonists have several other important therapeutic applications for? | Angina pectoris Migraines Heart failure |
Prototype drug: prazosin (Minipress) mechanism of action? | To inhibit the sympathetic nervous system |
prazosin (Minipress) primary use? | Hypertension, dysrhythmias, angina, heart failure, benign prostatic hypertrophy, narrow-angle glaucoma |
Adverse effects of Beta 1: | Dizziness, drowsiness, headache, loss of energy and strength, palpitations, dry mouth |
What to monitor with adrenergic blockers? | Urinary hesitancy, incomplete bladder emptying, interrupted urinary stream Monitor vital signs, level of consciousness, and mood. Monitor for dizziness, drowsiness, or light-headedness. Observe for side effects. Monitor cardiac output |
Prototype drug: phenylephrine (Neo- Synephrine). Mechanism of action? | To stimulate the sympathetic nervous system directly/indirectly |
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