teratogens Word Scramble
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| Question | Answer |
| Most susceptible for teratogenic effects | 3-8 weeks |
| Before 3 weeks effect:After 8 weeks: | Before 3 weeks: all-or-none, after 8 weeks: growth and function are affected |
| Alcohol | fetal alcohol syndrome, mental retardation |
| ACE inhibitors | Renal damage |
| Cocaine | abnormal fetal development and addication, placental abruption |
| Diethylstilbestrol (DES) | Vaginal clear cell adenocarcinoma |
| Iodide (lack/excess) | congenital goiter, hypothyroidism |
| Vitamin A (excess) | Extremely high risk for spontaneous abortions, birth defects (cleft palate, cardiac abnormalities) |
| Thalidomide | Limb defects (flipper limbs) |
| Smoking (nicotine, CO) | Pre-term labor, placental problems, IUGR, ADHD |
| X-rays, anticonvulsants | multiple anomalies |
| Warfarin | bone deformities, fetal hemorrhage, abortion |
| Tetracyclines | discolored teeth |
| Alkylating agents | absence of digits, multiple anomalies |
| aminoglycosides | CN VIII toxicity |
| Folate antagonists | NTD |
| Fetal alcohol syndrome | pre/post natal developmental retardation, microcephaly, holoprosencephaly, facial abnormalities, limb dislocation, heart/lung fistuals. Mechanism may include inhibition of cell migration. |
Created by:
ddecampo
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