Meperidine &Dilaudid Word Scramble
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Question | Answer |
Meperidine was discovered during search for synthetic _________-like drug. | atropine |
Meperidine causes a(n) (increase or decrease?) in HR. | increase |
Meperidine causes some large airway (bronchoconstriction or bronchodilation?) | bronchodilation |
Does meperidine cause myocardial depression? | yes, at doses above 2mg/kg |
True or False: meperidine is rarely used in the maintenance of anesthesia in adults. | True |
What causes N/V after meperidine administration? | sensitizes the labyrinth apparatus resulting in dizziness and N/V |
What is a common dose of meperidine? | 0.5-1mg/kg |
Meperidine is an opioid agonist at which receptors? | mu and kappa |
Compare meperidine's potency to morphine. | Meperidine is 1/10 as potent as morphine. |
Compare meperidine's solubility to morphine. | Meperidine is 11X more lipid soluble than morphine. |
_____% of meperidine is protein bound. | 60% |
How is meperidine metabolized? | by demethylation in the liver |
What is meperidine's metabolite? | normeperidine (90%) |
How is normeperidine metabolized? | excreted by kidneys |
Compare normeperidine's activity to meperidine's? | normeperidine is 1/2 as active as meperidine |
What is normeperidine's half-life in adults? in neonates? | 15hrs in adults, >30hrs in neonates |
What effect does normeperidine have on the body? | CNS stimulant; seizures w/ toxic levels of accumulation (Demerol dose of >5mg/kg; typically repeat doses or infusions) or renal failure |
What is a typical meperidine duration? | 2-4 hrs |
What is an IM dose of meperidine? and duration of IM dose? | 100mg IM q4hr; duration=1 hr 24min |
What is the most common post-op indication of the use of meperidine? | post-op shivering |
How dose meperidine decrease post-op shivering? | stimulation of kappa receptors or decreased shivering threshold; alpha2 receptor stimulation |
Does histamine displacement occur with meperidine administration? | yes, but less than morphine |
Oral absorption of meperidine is (better or worse?) than morphine/ | better |
Meperidine has (great or poor?) cough suppression. | poor |
What can happen when meperidine is given with antidepressant MAOI? | serotonin syndrome |
What are s/s of serotonin syndrome? | HTN, tachycardia, diaphoresis, hyperthermia, confusion, agitation, neuromuscular changes (hyperreflexia), coma, seizures, coagulopathy, metabolic acidosis |
True or False: Hydormorphone is a synthetic drug? | False: it is a semi-synthetic |
Are hydromorphone's metabolities active or inactive? | inactive |
Compare eqipotent doses of hydromorphone and morphine and fentanyl. | 1.5mg of hydromorphone to 10mg of morphine and 100mcg of fentanyl. |
What is a typical dose of hydromorphone? | 0.2-0.6mg/kg |
What is the onset of hydromorphone? | 5 min |
What is the duration of hydromorphone? | 4-5 hrs |
What is the elimination 1/2 life of hydromorphone? | 2-3 hrs |
Respiratory depression with hydromorphone is (more or less?) likely with opioid-naïve patients? | more |
Compare hydromorphone's euphoria to other opioids. | less euphoria |
How is hydromorphone metabolized? | phase II conjugation via glucuronic acid (similar to morphine) |
Created by:
lindseymontgomery
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