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Meperidine &Dilaudid
Pharm (Test 2)
| Question | Answer |
|---|---|
| Meperidine was discovered during search for synthetic _________-like drug. | atropine |
| Meperidine causes a(n) (increase or decrease?) in HR. | increase |
| Meperidine causes some large airway (bronchoconstriction or bronchodilation?) | bronchodilation |
| Does meperidine cause myocardial depression? | yes, at doses above 2mg/kg |
| True or False: meperidine is rarely used in the maintenance of anesthesia in adults. | True |
| What causes N/V after meperidine administration? | sensitizes the labyrinth apparatus resulting in dizziness and N/V |
| What is a common dose of meperidine? | 0.5-1mg/kg |
| Meperidine is an opioid agonist at which receptors? | mu and kappa |
| Compare meperidine's potency to morphine. | Meperidine is 1/10 as potent as morphine. |
| Compare meperidine's solubility to morphine. | Meperidine is 11X more lipid soluble than morphine. |
| _____% of meperidine is protein bound. | 60% |
| How is meperidine metabolized? | by demethylation in the liver |
| What is meperidine's metabolite? | normeperidine (90%) |
| How is normeperidine metabolized? | excreted by kidneys |
| Compare normeperidine's activity to meperidine's? | normeperidine is 1/2 as active as meperidine |
| What is normeperidine's half-life in adults? in neonates? | 15hrs in adults, >30hrs in neonates |
| What effect does normeperidine have on the body? | CNS stimulant; seizures w/ toxic levels of accumulation (Demerol dose of >5mg/kg; typically repeat doses or infusions) or renal failure |
| What is a typical meperidine duration? | 2-4 hrs |
| What is an IM dose of meperidine? and duration of IM dose? | 100mg IM q4hr; duration=1 hr 24min |
| What is the most common post-op indication of the use of meperidine? | post-op shivering |
| How dose meperidine decrease post-op shivering? | stimulation of kappa receptors or decreased shivering threshold; alpha2 receptor stimulation |
| Does histamine displacement occur with meperidine administration? | yes, but less than morphine |
| Oral absorption of meperidine is (better or worse?) than morphine/ | better |
| Meperidine has (great or poor?) cough suppression. | poor |
| What can happen when meperidine is given with antidepressant MAOI? | serotonin syndrome |
| What are s/s of serotonin syndrome? | HTN, tachycardia, diaphoresis, hyperthermia, confusion, agitation, neuromuscular changes (hyperreflexia), coma, seizures, coagulopathy, metabolic acidosis |
| True or False: Hydormorphone is a synthetic drug? | False: it is a semi-synthetic |
| Are hydromorphone's metabolities active or inactive? | inactive |
| Compare eqipotent doses of hydromorphone and morphine and fentanyl. | 1.5mg of hydromorphone to 10mg of morphine and 100mcg of fentanyl. |
| What is a typical dose of hydromorphone? | 0.2-0.6mg/kg |
| What is the onset of hydromorphone? | 5 min |
| What is the duration of hydromorphone? | 4-5 hrs |
| What is the elimination 1/2 life of hydromorphone? | 2-3 hrs |
| Respiratory depression with hydromorphone is (more or less?) likely with opioid-naïve patients? | more |
| Compare hydromorphone's euphoria to other opioids. | less euphoria |
| How is hydromorphone metabolized? | phase II conjugation via glucuronic acid (similar to morphine) |
Created by:
lindseymontgomery
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