Chapter 12 GENE Word Scramble
|
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.
Normal Size Small Size show me how
Normal Size Small Size show me how
Question | Answer |
Tumor suppressant genes | Prevent growth |
Oncology | Study of tumors (aka neoplasm) An abnormal growth of tissue |
Benign | Non-invasive, non- metastatic tumor |
Malignant | "Badly born", tumor characterized by anaplasia, invasiveness and metastasis |
Anaplasia | Rapidly dividing, undifferentiated cells |
Metastasis | Spread of cancer to other body sites |
Categories of malignant neoplasia | All end in -oma |
Carcinoma | Ectodermal cells |
Sarcoma | Mesodermal cells |
Leukemia | White blood cells- myeloid or lymphoid lineages |
Lymphoma | Macrophages and cells of the lymphatic system |
Familial | Inherited predisposition, mutations are carrier in all cells, recessive at cellular level but inherited as a dominant trait as new somatic mutations accumulate (organism level= dominant) |
Sporadic | Spontaneous mutations |
Cancer is a ____ disease. | genetic |
Primary risk factor for cancer | Age |
Stages in cancer cell | Metaplasia, dysplasia, anaplasia, extravasation |
Intravasation | Enter into bloodstream of cancer cells |
Extravasation | Exit from bloodstream of cancer cells |
Cancer is caused by... | An inherited susceptibility or a sporadic event. |
Mutator genes | Do not cause cancer directly but result in genome instability and increased mutation rate (cancer syndromes) |
Oncogenes | Increase cell division (proliferative) |
Why aren't mutations in proto- oncogenes found among familiar types of cancer? | 1. Mutations in DNA repair genes indirectly cause "cancer syndromes" 2. Retinoblastoma |
Retinoblastoma | A malignant tumor of the eye arising in retinoblasts (embryonic retinal cells that disappear at about 2 years of age.) Because mature retinal cells do not transform into tumors, this tumor usually occurs only in children. Deletion long arm chromosome 13 |
RB1 Gene | The tumor- suppressing protein pRB controls the G1/S transition in the cell cycle, without pRB, cell division in uncontrolled |
Polyps | Growths attached to the substrate by small stalks. Commonly found in nose, rectum, and uterus |
Created by:
tstrange
Popular Science sets