antibiotics prt 1 Word Scramble
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Question | Answer |
which drugs inhibit DNA synthesis and integrity | Sulfanomides, Trimethoprim, Quinolones |
Which drugs inhibit cell wall synthesis | Vancomycin, Monobactams, crbapenems, Penicillin, cephalosporins |
which drugs inhibit transcripotion and translation | Aminoglycosides tetracycline, streptogrammins, lincosamiees, chlorampheticol, macrolides |
differentiate gram negative from gram positive | gram negative has the cell wall in beterrn 2 membranes and gram positive has cell wall covered in murin |
what makes bacteria cell wall firm adn rigid? | peptidoglycan |
what will substitutions at beta lactam rings effect? | solubility weather oral or not, resistence to beta lactamase, spetrum of activity - either gram neg or positive |
how do betalactams and vaco effect cell wall? | it inhibits peptdoglycan synthesis |
what class is vancomycin | glycopeptide antibiotic |
what are major reactions of penicillin? | since we dont have cell walls major interactionsare hypersensitivity / allergic. or GI |
what is transpeptidase? | links the peptides together needed to make peptidoglycans or cell wall |
what is PBP | penicillin binding protein or transpeptidas |
what do beta lactams inhibit? | Transpeptidase |
whats the biggest drawback of using penicillin? | the emergence of beta lactamse |
what do penicillins work against? | gram positive, non beta lactamase anaerobes |
Nafcillin | anti-stappylococcal pnc |
methicillin | antistaphylococci penicillin |
which antibiotics are more broader range? | nafcillin, methicillin |
which antibiotics are extended spectru,m? | ampicillin, amoxicillin |
which drugs are beta lactamase inhibitors? | clavulanic acid, sulbactam, tazobactam |
what is unasyn | ampicillin and sulbactam |
what is augmentin | amoxicillin and claulanic acid |
zosyn | pipercillin/tazobactam |
ampicillina nd sulbactam | unasyn |
amoxicillin and clavulanic acid | augmentin |
pipercillin/tazobactam | zosyn |
how to beta lactam inhibitors work? | beta lactamase think they are beta lactam righs they are confused and fooled because it is structurally different ties them up with the beta lactam inhibitors |
penicillins are cleared vuia what/ | renal |
what is important to know about oral penacillin? | give on an empty stomach except with amoxicillin may be given without reguard |
major adverse effects of pnc | hypersensitivity |
what are ways bacteria can become resistant to beta lactams? | inactivation by beta lactamase, mutation of pbp- very common, impaired penitration to drug, presence of efflux pump |
why were cephalosporins made? | they re chemically structurally and mechanastically similar to PNC but more stable against beta lactamse |
describe first generation cephalosporinq | limite range of activity |
has excellent resistant to most beta lactamse | cefepim 4th generation |
against penicillin resistant streptococci | cefepim 4th generation |
against MRSA, VRSA, VISA | Ceftaroline (teflaro) |
treatment of meningitic from pneymococci | ceftriaxone and cefotaxime add vancomycin for more coverage |
Created by:
Cherry5301
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