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antibiotics prt 1

which drugs inhibit DNA synthesis and integrity Sulfanomides, Trimethoprim, Quinolones
Which drugs inhibit cell wall synthesis Vancomycin, Monobactams, crbapenems, Penicillin, cephalosporins
which drugs inhibit transcripotion and translation Aminoglycosides tetracycline, streptogrammins, lincosamiees, chlorampheticol, macrolides
differentiate gram negative from gram positive gram negative has the cell wall in beterrn 2 membranes and gram positive has cell wall covered in murin
what makes bacteria cell wall firm adn rigid? peptidoglycan
what will substitutions at beta lactam rings effect? solubility weather oral or not, resistence to beta lactamase, spetrum of activity - either gram neg or positive
how do betalactams and vaco effect cell wall? it inhibits peptdoglycan synthesis
what class is vancomycin glycopeptide antibiotic
what are major reactions of penicillin? since we dont have cell walls major interactionsare hypersensitivity / allergic. or GI
what is transpeptidase? links the peptides together needed to make peptidoglycans or cell wall
what is PBP penicillin binding protein or transpeptidas
what do beta lactams inhibit? Transpeptidase
whats the biggest drawback of using penicillin? the emergence of beta lactamse
what do penicillins work against? gram positive, non beta lactamase anaerobes
Nafcillin anti-stappylococcal pnc
methicillin antistaphylococci penicillin
which antibiotics are more broader range? nafcillin, methicillin
which antibiotics are extended spectru,m? ampicillin, amoxicillin
which drugs are beta lactamase inhibitors? clavulanic acid, sulbactam, tazobactam
what is unasyn ampicillin and sulbactam
what is augmentin amoxicillin and claulanic acid
zosyn pipercillin/tazobactam
ampicillina nd sulbactam unasyn
amoxicillin and clavulanic acid augmentin
pipercillin/tazobactam zosyn
how to beta lactam inhibitors work? beta lactamase think they are beta lactam righs they are confused and fooled because it is structurally different ties them up with the beta lactam inhibitors
penicillins are cleared vuia what/ renal
what is important to know about oral penacillin? give on an empty stomach except with amoxicillin may be given without reguard
major adverse effects of pnc hypersensitivity
what are ways bacteria can become resistant to beta lactams? inactivation by beta lactamase, mutation of pbp- very common, impaired penitration to drug, presence of efflux pump
why were cephalosporins made? they re chemically structurally and mechanastically similar to PNC but more stable against beta lactamse
describe first generation cephalosporinq limite range of activity
has excellent resistant to most beta lactamse cefepim 4th generation
against penicillin resistant streptococci cefepim 4th generation
against MRSA, VRSA, VISA Ceftaroline (teflaro)
treatment of meningitic from pneymococci ceftriaxone and cefotaxime add vancomycin for more coverage
Created by: Cherry5301