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Metabolism

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Metabolism   The sum of all chemical transformations taking place in a cell. The overall process by which living systems acquire and utilize energy. The overall network of enzyme catalyzed reaction pathways.  
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Metabolic Pathways   Linear Pathway: glycolysis Branched Pathway: amino acid biosynthesis Cyclic Pathway: citric acid cycle.  
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Network Nature of Metabolism   Initial reactants vs. intermediates vs. final products.  
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Metabolic Pathways   Linear Pathway: glycolysis Branched Pathway: amino acid biosynthesis Cyclic Pathway: citric acid cycle  
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Anabolism   build large molecules, require ATP, divergent pathways  
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Pharmacy relevance   Must be spontaneous: thermodynamically favorable, negative delta G  
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Oxidizing Agent   removes electrons from another reactant in a redox reaction. the oxidizing agent is reduced.  
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Redox Reactions   An oxidizing agent (also called an oxidant, oxidizer or oxidiser) can be defined as a substance that removes electrons from another reactant in a redox chemical reaction. The oxidizing agent is reduced. Having electrons taken away.  
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delta G prime   standard free energy when all components = 1.0M at pH7, 25C 1 atm.  
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delta G   actual free energy change under cellular conditions.  
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Free energy changes during chemical reactions   negative delta G: spontaneous positive delta G: need coupled reactions, Hess' Law zero delta G: Lechatelier's Principle.  
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large Keq   spontaneous, large -deltaG or very negative delta G.  
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phosphoryl group transfer details   special role of ATP as the energy currency that links catabolism and anabolism. use ATP to drive: anabolism, mechanical motion, & active transport.  
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Reverse Reactions   Same absolute value just change the sign.  
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Importance of ATP intermediate phosphoryl transfer potential   It is in the middle and may drive other reactions.  
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Regulation of metabolic pathways   catabolic pathways are only activated when it is needed.  
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phosphocreatine during exercise   100m sprint fast-twitch muscle uses phosphocreatine to generate ATP. marathon- slow-twitch muscle uses slow and steady process of nutrient catabolism/oxidative phosphorylation(mitochondria)  
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Fats   Most Energy; fatty acids.  
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