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Medical Biochem
Metabolism
Question | Answer |
---|---|
Metabolism | The sum of all chemical transformations taking place in a cell. The overall process by which living systems acquire and utilize energy. The overall network of enzyme catalyzed reaction pathways. |
Metabolic Pathways | Linear Pathway: glycolysis Branched Pathway: amino acid biosynthesis Cyclic Pathway: citric acid cycle. |
Network Nature of Metabolism | Initial reactants vs. intermediates vs. final products. |
Metabolic Pathways | Linear Pathway: glycolysis Branched Pathway: amino acid biosynthesis Cyclic Pathway: citric acid cycle |
Anabolism | build large molecules, require ATP, divergent pathways |
Pharmacy relevance | Must be spontaneous: thermodynamically favorable, negative delta G |
Oxidizing Agent | removes electrons from another reactant in a redox reaction. the oxidizing agent is reduced. |
Redox Reactions | An oxidizing agent (also called an oxidant, oxidizer or oxidiser) can be defined as a substance that removes electrons from another reactant in a redox chemical reaction. The oxidizing agent is reduced. Having electrons taken away. |
delta G prime | standard free energy when all components = 1.0M at pH7, 25C 1 atm. |
delta G | actual free energy change under cellular conditions. |
Free energy changes during chemical reactions | negative delta G: spontaneous positive delta G: need coupled reactions, Hess' Law zero delta G: Lechatelier's Principle. |
large Keq | spontaneous, large -deltaG or very negative delta G. |
phosphoryl group transfer details | special role of ATP as the energy currency that links catabolism and anabolism. use ATP to drive: anabolism, mechanical motion, & active transport. |
Reverse Reactions | Same absolute value just change the sign. |
Importance of ATP intermediate phosphoryl transfer potential | It is in the middle and may drive other reactions. |
Regulation of metabolic pathways | catabolic pathways are only activated when it is needed. |
phosphocreatine during exercise | 100m sprint fast-twitch muscle uses phosphocreatine to generate ATP. marathon- slow-twitch muscle uses slow and steady process of nutrient catabolism/oxidative phosphorylation(mitochondria) |
Fats | Most Energy; fatty acids. |