Mental Health
Quiz yourself by thinking what should be in
each of the black spaces below before clicking
on it to display the answer.
Help!
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| Name the seven tricyclic & Cyclic drugs for antidepressant? | Elavil
Pamelor,Sinequan
,Torfranil,Remeron,
Asendin, Anafranil
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| Name the 5 SSRI's? | Prozac,Paxil,Zoloft,Celexa,
Lexapro
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| Name the three MAOi's? | Nardil,Parnate,Marplan
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| Name 2nd Gen antidepressants? | Wellbutrin,Desyrel(trazodone)
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| Name 3rd Gen antidepressants? | Serzone,Cymbalta,Effexor
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| How do Tricyclic Drugs work? | Block reuptake of norepinephrine and to a lesser degree of serotonin into the presynaptic cell.
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| Side Effects of Tricyclic antidepressants? | Due to block other receptors such as:
Muscarinic receptors also-ANTICHOLINERGIC s/e:blurred vision,urine retention,constipation,
A1:blocks the pressor response necessary to avoid Orthostatic Hypotentsion
Ratio to toxic dose is very low: Death
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| How SSRI's work? | BLock the reuptake of serotonin back into the presynaptic space, decrease destruction of transmitter and there is more serotonin at synapse for the postsynaptic cell.
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| Key Points about SSRI's | -Do not block other receptors-less side effects
-ONLY effective in mild or moderate depression
-good choice for impulsive or suicidal bc no risk of lethal overdose
-4-6 weeks before meds take effect,monitor suicide, maybe more energized but still have
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| Side effects of SSRI's | Nausea- take with food
weight gain- least amount compared to others
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| How MOAi's work? | inhibits the ability of the enzyme to destroy the monoamines:norepinephrine,dopamine,serotonin. Eventually leads to presynaptic,synaptic,and postsynaptic concentrations of these neurotransmitters.
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| Key points of MAOi's | -MAO is present in the liver cells as well as monoamine-releasing neurons.
-Inactivation of hepatic MAO by MAO-inhibiting drugs can lead to potentially fatal interaction between these drugs and foods.
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| Very important about MAO! | MAO inhibited in liver---build up of serum tyramine----triggers sudden release of norephineprine(potent vasoconstrictor)-----Hypertensive CRISIS:hypertension,tachycardia,doaphoresis,hyperpyrexia,cardiac arrythmias, tremulousness
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| Foods that contain Tyramine to avoid while on MAOI's | aged cheese,aged meats:peperoni,summer sausage,all tap beers,overripe fruit,yogurt,peanuts,
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| Wellbutron | can cause seizures 4x that of other antidepressants, contraindicated if seizure disorder as lowers seizure threshold
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