Neonate Infection
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| give examples of physical barriers | skin, mucous membranes, blood brain barrier
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| chemical barriers include, | stomach acid, F.A.'s in skin, enzymes and proteins, saliva tears and mucous
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| cellular immunity includes | phagocytes(macrophage, lymphocytes), ctotoxic killer T-cells, monocytes, neutrophils etc
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| IgG is synthesised from... | 12-15W
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| what percentage of the immunoglobulin pool is made of IgG | 75%
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| what is IgA found in | saliva, tears, colostrum and breastmilk
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| when is IgA synthesised | 30W
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| what is IgM part of | the primary response to infection
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| when is IgM synthesised | 15W
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| what is IgE effective against | parastic infections (i.e.toxoplasmosis)
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| what is opsonization? | process of recognition of antigenic material previously experienced and the subsequent antibody reaction decreasing reaction time
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| name four ways of reducing infection | vernix, breastfeeding, indivdual equipment, handwashing
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| name the three periods of infection | transplacental (small viruses),
Ascending (PROM,chorioamnmioitis),
Postpartum ->most susceptible
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| when does GBStrep present in the neonate | within 4-6hours
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| what does GBStrep cuase in the baby | respiratory failure and shock followed by collapse
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| how is toxoplasmosis diagnosed in the fetus | DNA from amniotic fluid
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| what are the clinical features of a baby who has contracted toxoplasmosis? | hydrocephalus, epilepsy, chorioretintis, liver disease, myocardial impairment, SGA
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| what are the clinical features of a baby who was subjected to rubella | SGA cataracts, deafness, microcephaly, rubella ostetitis, cardiac abnormalities, liver damage...
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| what are some clinincal features of a baby subjected to cytomegalovirus | SGA if congenital, intracerebral calcification, chorio retinitis, deafness
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| how can a fetus contract herpes | vertical transmission during labour
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| what can herpes cause in the fetus | central nervous system disease, blindness
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| how is herpes diagnosed | the presence of vesicles
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| what is herpes in the neonate treated with | actyclovir
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| how is syphilis transmitted to the fetus | transplacentally
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| what are the consequences of a fetus contracting syphilis | organomegaly, osteochondria, meningitis, hydrocephaly
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| how is syphilis treated in pregnancy | penicillin
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| how is chlamydia contracted | vertical transmission
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| when does chlamydia present in the neonate | 5-12 days postnatally
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| what are the symptoms of chlamydia in the neonate | watery discharge from the eye
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| how is chlamydia treated | tetracycline for both mum and baby
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| what are the consequences of a gonoccal eye infection | damaged cornea
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| how is a gonoccal eye infection treated | systemic penicillin and penicillin eye drops, isolate mother and baby!!
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| what is the most common cause of paronychia | staph aureus
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| how is paronychia treated | oral flucloxicillin
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| what are common causes of umbilical cord infection | Staph Aureus, E. Coli, Klebsiella
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| what are the treatment options for an umbilical cord infection | topical-chlohexidene powder
if severe-> IV antibiotics
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| how is a local infection of candida treated | nystatin
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| what treatments can be used to treat a systemic candida infection | amphotericin, flucytosine, fluconazole
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| true or flase- HIV +ve women with a high viral load appear to be at greater risk of transmitting infection | true
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| name an antiretroviral drug given in pregnancy | zidovudine
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| what are some symptoms indicating a neonate may have contracted HIV | poor growth, repiratory infections, uncommon co-infections i.e. cmv herpes etc
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Created by:
KerriPatton
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