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Pathophysiology

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Question
Answer
DNA   the nucleic acid that contains all of an individuals genes  
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Genes   a region on DNA that contains the "code" for making one protein  
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Alleles   Different forms of a gene  
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Dominant   an allele that is always expressed  
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recessive   an allele that will be expressed only when a person is homozygous. it an be "hidden"  
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Genotype   a two letter code that describes which alleles a person has  
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Homozygous   Having the same 2 alleles  
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Heterozygous   having different alleles for a gene  
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Expressed   the allele that we can see evidence of  
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phenotype   describes what characteristics are produced as a result of having a certain genotype  
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chromosomes   the combination of DNA and proteins found in a cell that is going through mitosis (humans have 23 pair)  
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autosomes   chromosome pairs 1-22  
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sex chromosomes   the 23rd pair of chromosomes in humans  
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karyotype   describes the microscopic appearance of the chromosomes  
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diploid   having the normal 23 pairs of chromosomes  
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aneuploid   having an abnormal number of chromosomes  
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monosomy   missing one chromosome  
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trisomy   having an extra copy of a chromosome  
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hematocrit   the percentage of blood volume occupied by RBC  
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mean corpuscular volume MVC   the average size of a RBC  
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anemias   s group of diseases that decreases the ability of blood to carry oxygen  
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luekemias   a group of diseases that results in a dramatic increase in the number of leukoblasts  
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polycythemia   having abnormally high number of RBC  
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pancytopenia   a decrease in the number of all normal blood cells  
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erythrocytopenia   a decrease in the number of RBC  
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leukopenia   a decrease in the number of white blood cells  
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thrombocytopenia   having a low number of platelets  
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hemophilia   a genetic decrease in the activity of one of the clotting factors  
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thallasemias   a group of genetic anemias resulting in a decrease in the synthesis of globin chains  
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intrinsic factor   any factor from within the body  
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extrinsic factor   any factor coming from outside the body  
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intrinsic factor for pernicious anemia   a protein secreted by gastric glands that is needed for b12 absorption  
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extrinsic factor for pernicious anemia   vitamin b12  
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auscultation   any diagnostic procedure that listens to body sounds  
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echocardiography   an ultra sound of the heart  
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stress test   an electrocardiogram performed while the heart rate is elevated  
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angiography   a contrast x-ray showing circulation  
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cardiac markers   proteins released from damaged cardiac tissue into the blood; used as diagnostic indicator of myocardial infarction  
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normal sinus rhythm   having a normal heart rhythm established by the sinoatrial node  
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bradycardia   resting heart rate of <60 beats per minute  
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tachycardia   resting heart rate of >100 beats per minute  
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valvular incompetence   the inability of valve to either open or close properly  
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valvular stenosis   the inability of a valve to open completely  
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valvular prolapse   when one of the AV valves swings up into the atrium when it should be closed  
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atheroscelerosis   hardening of the arteries  
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arteriostenosis   narrowing of the arteries  
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ischemia   a local decrease in blood flow due to obstruction  
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angina pectoris   chest pains as a result of myocardial ischemia  
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myocardial infarctions   ischemic necrosis of heart muscle. heart attack  
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TIA   a temporary decrease in cerebral function as a result of ischemia  
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cerebral infarction   ischemic necrosis of the cerebrum. stroke  
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secondary hypertension   chronic high BP that is a complication of another condition  
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primary hypertension   chronic high BP of unknown origin  
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aneurysm   localized dilation of an artery or chamber of the heart as a result of a weakness in the wall  
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hemoptysis   coughing up blood fro the lungs  
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hypoxia   a lack of oxygen  
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hypercapnea   an excess of carbon dioxide  
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respiratory acidosis   a decrease in the PH of body fluids as a result of the build up of carbon dioxide  
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atelectasis   a partial or complete collapse of lung tissue  
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pneumothorax   the presence of air between the visceral pleura and the parietal pleura  
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bullae   a group of over inflated alveoli  
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ulcer   a lesion through the skin or mucous membrane  
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peptic ulcer   a lesion caused by pepsin  
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duodenal ulcer   a lesion in the mucosal lining of the duodenum  
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gastric ulcer   a lesion in the mucosal lining of the stomach  
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esophageal ulcer   a lesion in the mucosal lining of the esophagus  
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diverticulum   a pouch or sac that develops off of a tubular structure such as the intestine  
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diverticulitis   inflammation of a pouch or sac opening off of a tubular structure  
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diverticulosis   the presence of diverticulum in the intestines  
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cholelithiasis   the presence of stones within the gall bladder or biliary ducts  
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neuropathy   a disease of nervous tissue  
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myopathy   a disease of muscle tissue  
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intravenous pyelogram   a contrast x-ray showing the structures that carry urine  
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bun   a blood test used as an indicator of kidney function. measures the quantity or urea which is a waste product of protein metabolism  
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creatinine clearance   a measure of kidney function that compares the quantity of creatinine excreted in the urine over a 24 hour period to the concentration of creatinine in the blood  
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cystoscopy   using an endoscope to examine the urinary bladder  
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