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lorazepam

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Question
Answer
Ativan's generic/chemical name   lorazepam  
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Ativan is an   anxiolytic, benzodiazepine  
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lorazepam adult dose   PO 2-6 mg/d with max of 10 mg/d  
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Ativan contraindication 1   hypersensitivity  
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Ativan contraindication 2   CNS depression  
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Ativan contraindication 3   shock  
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Ativan contraindication 4   coma  
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Ativan contraindication 5   narrow-angle glaucoma  
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Ativan contraindication 6   pregnancy & lactation  
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lorazepam food drug 1   increases CNS depression when taken w/alcohol  
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lorazepam food drug interactions 2   CNS depression  
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lorazepam food drug interactions 3   anticonvulsants  
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lorazepam food drug interactions 4   cimetidine increase plasma levels of drug  
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lorazepam food drug interactions 5   increase phenoytoin levels  
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lorazepam food drug interactions 6   decrease *levodopa effects  
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lorazepam food drug interactions 7   Smoking decreases antianxiety effects  
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Ativan and Kava Kava may   potentiate sedation  
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lorazepam is absorbed   rapidly in GI tract  
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PB   85%  
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t 1/2   12-14 h  
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lorazepam is excreted   urine  
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Ativan onset   UK  
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Ativan peak   2 h  
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lorazepam duration   12-24 h  
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Ativan's 3 therapeutic effects   1. control anxiety. 2.treat *status epilepticus. 3.preoperative sedation  
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lorazepam's mode of action   potentiate gamma-aminobutyric (GABA) effects by binding to specific benzodiazepine receptors and INHIBITING GABA neurotransmission  
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Side effects of Ativan   drowsiness, dizziness, weakness, confusion, blurred visin, nausea, vomiting, anorexia, sleep disturbance, restlessness, hallucinations.  
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Adverse reactions of lorazepam   hypertension, hypotension  
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Nursing assessment 1   assess for suicidal ideation  
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Nursing assessment 2   Obtain hx of client's anxiety reaction  
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Nursing assessment 3   Determine client's support system  
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Nursing assessment 4   obtain drug hx, report possible drug-drug interactions  
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Possible nursing diagnoses   1.Anxiety r/t panic. 2.Impared physical mobility r/t drowsiness and weakness.  
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Nursing Intervention 1   Observe client for side effects of anxiolytics. Recognize drug tolerance, physical, psychological dependency can occur.  
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Nursing Intervention 2   anxiolytic dosages should be lower for older adults, children, debilitated persons  
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Nursing Intervention 3   monitor VS, especially B/P and pulse. Ortostatic hypotension.  
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Nursing Intervention 4   encourage family to be supportive of client  
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General teaching 1   advise pt not to drive while taking anxiolytics  
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General teaching 2   instruct pt not to consume alcohol  
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General teaching 3   teach pt to control excess stress & anxiety  
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General teaching 4   encourage pt to follow drug regimen and not to abruptly stop taking the drug after prolonged use b/c withdrawl symtoms can occur- dose is usually tappered.  
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Side effects   orthostatic hypotension & dizziness; teach pt to rise slowly from sitting to standing  
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